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    TWNK twinkle mtDNA helicase [ Gallus gallus (chicken) ]

    Gene ID: 425626, updated on 3-Dec-2024

    Summary

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    Official Symbol
    TWNKprovided by CGNC
    Official Full Name
    twinkle mtDNA helicaseprovided by CGNC
    Primary source
    CGNC:13117
    See related
    Ensembl:ENSGALG00010018482
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PEO1; C10orf2; C6H10orf2
    Orthologs
    human mouse all
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    Genomic context

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    See TWNK in Genome Data Viewer
    Location:
    chromosome: 6
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 6 NC_052537.1 (23871056..23874659, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 6 NC_052578.1 (23762264..23765870, complement)

    Chromosome 6 - NC_052537.1Genomic Context describing neighboring genes Neighboring gene sideroflexin 3 Neighboring gene PDZ domain containing 7 Neighboring gene leucine zipper tumor suppressor 2 Neighboring gene mitochondrial ribosomal protein L43 Neighboring gene semaphorin 4G Neighboring gene SMC5-SMC6 complex localization factor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 5'-3' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    twinkle mtDNA helicase
    Names
    progressive external ophthalmoplegia 1 protein homolog
    twinkle protein, mitochondrial
    NP_001026515.1
    XP_015144178.2
    XP_046776347.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031344.2 → NP_001026515.1  twinkle mtDNA helicase precursor

      See identical proteins and their annotated locations for NP_001026515.1

      Status: PROVISIONAL

      Source sequence(s)
      JAENSK010000232
      UniProtKB/Swiss-Prot
      Q5ZIW1
      UniProtKB/TrEMBL
      A0A8V0Z659
      Related
      ENSGALP00010026630.1, ENSGALT00010044708.1
      Conserved Domains (2) summary
      cd01029
      Location:265 → 341
      TOPRIM_primases; TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG ...
      cd01122
      Location:380 → 637
      GP4d_helicase; GP4d_helicase is a homohexameric 5'-3' helicases. Helicases couple NTP hydrolysis to the unwinding of nucleic acid duplexes into their component strands.

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      23871056..23874659 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015288692.4 → XP_015144178.2  twinkle mtDNA helicase isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z659
      Conserved Domains (2) summary
      cd01029
      Location:265 → 341
      TOPRIM_primases; The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG type primases are ...
      cl38936
      Location:371 → 529
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      23762264..23765870 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046920391.1 → XP_046776347.1  twinkle mtDNA helicase isoform X1

      UniProtKB/TrEMBL
      A0A8V0Z659
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q5ZIW1.1 GenPept UniProtKB/Swiss-Prot:Q5ZIW1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.