SKIL SKI like proto-oncogene [Gallus gallus (chicken)] - Gene

Summary

Symbol: SKILprovided by CGNC
Full Name: SKI like proto-oncogeneprovided by CGNC
Primary source: CGNC:7113
See related: Ensembl:ENSGALG00010016675
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: SNO; c-sno
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	9	NC_052540.1 (19491868..19508424, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	9	NC_052581.1 (19279908..19296486, complement)

Chromosome 9 - NC_052540.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SnoN (SKIL) is expressed in the tip of the growing digit cartilage primordia, and in the developing joints. The addition of TGF beta in micromass cultures is quickly followed by an intense up-regulation of this TGF beta-signaling repressor.
Title: Transforming growth factors beta coordinate cartilage and tendon differentiation in the developing limb mesenchyme.
SnoN is directly regulated by sumoylation leading to the enhancement of the ability of SnoN to repress transcription in a promoter-specific manner
Title: Sumoylated SnoN represses transcription in a promoter-specific manner.

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General gene information

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Markers

SCW0251 (e-PCR), detects polymorphism
- UniSTS:280343

SNONsts1 (e-PCR), detects polymorphism
- UniSTS:280359

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables SMAD binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: ski-like protein

Names: SKI-like oncogene; ski-related; snoN

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_205174.3 → NP_990505.2 ski-like protein

Status: VALIDATED

Source sequence(s)

JAENSK010000240

UniProtKB/TrEMBL

F1P0N0, Q05951

Related

ENSGALP00010023306.1, ENSGALT00010040198.1

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

19491868..19508424 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046898327.1 → XP_046754283.1 ski-like protein isoform X1

UniProtKB/TrEMBL

F1P0N0, Q05951
XM_046898328.1 → XP_046754284.1 ski-like protein isoform X1

UniProtKB/TrEMBL

F1P0N0, Q05951

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

19279908..19296486 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046923622.1 → XP_046779578.1 ski-like protein isoform X1

UniProtKB/TrEMBL

Q05951
XM_046923623.1 → XP_046779579.1 ski-like protein isoform X1

UniProtKB/TrEMBL

Q05951