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    MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like [ Gallus gallus (chicken) ]

    Gene ID: 421633, updated on 17-Aug-2024

    Summary

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    Symbol
    MTHFD1Lprovided by CGNC
    Full Name
    methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 likeprovided by CGNC
    Primary source
    CGNC:9427
    See related
    Ensembl:ENSGALG00010005610
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See MTHFD1L in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (48325670..48468005)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (48227744..48369905)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene iodotyrosine deiodinase Neighboring gene pleckstrin homology and RhoGEF domain containing G1 Neighboring gene uncharacterized LOC101751253 Neighboring gene A-kinase anchoring protein 12

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables formate-tetrahydrofolate ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables methylenetetrahydrofolate dehydrogenase (NADP+) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tetrahydrofolate interconversion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    monofunctional C1-tetrahydrofolate synthase, mitochondrial
    XP_004935674.2
    XP_025004698.2
    XP_040522291.1
    XP_040522292.1
    XP_040522293.1
    XP_040522295.1
    XP_040522296.1
    XP_040553585.1
    XP_040553587.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      48325670..48468005
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_004935617.5 → XP_004935674.2  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8V0XPZ8, A0A8V0XSP4
      Related
      ENSGALP00010007976.1, ENSGALT00010013446.1
      Conserved Domains (3) summary
      cd05212
      Location:157 → 291
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:308 → 934
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:39 → 249
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    2. XM_040697651.2 → XP_040553585.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X2

      Conserved Domains (3) summary
      cd05212
      Location:157 → 291
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PRK14191
      Location:36 → 250
      PRK14191; bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD
      PLN02759
      Location:308 → 436
      PLN02759; Formate--tetrahydrofolate ligase

    3. XM_025148930.3 → XP_025004698.2  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X4

      Conserved Domains (3) summary
      cd05212
      Location:157 → 291
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PRK14191
      Location:36 → 250
      PRK14191; bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD
      PLN02759
      Location:308 → 420
      PLN02759; Formate--tetrahydrofolate ligase

    4. XM_040697653.1 → XP_040553587.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X3

      Conserved Domains (1) summary
      PLN02759
      Location:1 → 501
      PLN02759; Formate--tetrahydrofolate ligase

    RNA

    1. XR_003074319.3 RNA Sequence

    2. XR_005858257.2 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      48227744..48369905
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040666357.2 → XP_040522291.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1

      UniProtKB/TrEMBL
      A0A8V0XSP4
      Conserved Domains (3) summary
      cd05212
      Location:157 → 291
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:308 → 934
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:39 → 249
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    2. XM_040666358.2 → XP_040522292.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X5

      UniProtKB/TrEMBL
      A0A8V0XSP4
      Conserved Domains (3) summary
      cd05212
      Location:157 → 291
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PLN02759
      Location:308 → 847
      PLN02759; Formate--tetrahydrofolate ligase
      COG0190
      Location:39 → 249
      FolD; 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme transport and metabolism]

    3. XM_040666359.2 → XP_040522293.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X2

      Conserved Domains (3) summary
      cd05212
      Location:157 → 291
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PRK14191
      Location:36 → 250
      PRK14191; bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD
      PLN02759
      Location:308 → 442
      PLN02759; Formate--tetrahydrofolate ligase

    4. XM_040666362.2 → XP_040522296.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X4

      Conserved Domains (3) summary
      cd05212
      Location:157 → 291
      NAD_bind_m-THF_DH_Cyclohyd_like; NAD(P) binding domain of methylene-tetrahydrofolate dehydrogenase and methylene-tetrahydrofolate dehydrogenase/cyclohydrolase
      PRK14191
      Location:36 → 250
      PRK14191; bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD
      PLN02759
      Location:308 → 420
      PLN02759; Formate--tetrahydrofolate ligase

    5. XM_040666361.1 → XP_040522295.1  monofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X3

      Conserved Domains (1) summary
      PLN02759
      Location:1 → 501
      PLN02759; Formate--tetrahydrofolate ligase

    RNA

    1. XR_005847690.2 RNA Sequence

    2. XR_005847691.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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