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    LIG3 DNA ligase 3 [ Gallus gallus (chicken) ]

    Gene ID: 417530, updated on 3-Dec-2024

    Summary

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    Symbol
    LIG3provided by CGNC
    Full Name
    DNA ligase 3provided by CGNC
    Primary source
    CGNC:1632
    See related
    Ensembl:ENSGALG00010029631
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See LIG3 in Genome Data Viewer
    Location:
    chromosome: 19
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 19 NC_052550.1 (4989787..5005069, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 19 NC_052591.1 (4718210..4733486, complement)

    Chromosome 19 - NC_052550.1Genomic Context describing neighboring genes Neighboring gene RAD51 paralog D Neighboring gene ring finger and FYVE like domain containing E3 ubiquitin protein ligase Neighboring gene uncharacterized LOC121107263 Neighboring gene uncharacterized LOC101747457 Neighboring gene uncharacterized LOC101747270

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates. Paul K, et al. PLoS One, 2013. PMID 23555685, Free PMC Article
    2. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. functional flexibility and interchangeability between LIG1 and LIG3
      Title: DNA ligases I and III cooperate in alternative non-homologous end-joining in vertebrates.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA ligase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA recombination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in base-excision repair, DNA ligation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in double-strand break repair via alternative nonhomologous end joining IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in lagging strand elongation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitochondrial DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of DNA ligase III-XRCC1 complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA ligase 3
    Names
    ligase III, DNA, ATP-dependent
    NP_001006215.3
    XP_015151212.2
    XP_040506000.1
    XP_040506001.1
    XP_046786000.1
    XP_046786001.1
    XP_046786002.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001006215.3 → NP_001006215.3  DNA ligase 3

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000323
      UniProtKB/TrEMBL
      A0A8V1ALB9
      Related
      ENSGALP00010044335.1, ENSGALT00010071645.1
      Conserved Domains (3) summary
      PLN03123
      Location:115 → 222
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      TIGR00574
      Location:335 → 847
      dnl1; DNA ligase I, ATP-dependent (dnl1)
      cd18431
      Location:933 → 1006
      BRCT_DNA_ligase_III; BRCT domain of DNA ligase 3 (LIG3) and similar proteins

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052550.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      4989787..5005069 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040650066.2 → XP_040506000.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8V1ALB9
      Conserved Domains (2) summary
      PLN03123
      Location:115 → 222
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      TIGR00574
      Location:335 → 844
      dnl1; DNA ligase I, ATP-dependent (dnl1)

    2. XM_040650067.2 → XP_040506001.1  DNA ligase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8V1ALB9
      Conserved Domains (2) summary
      PLN03123
      Location:115 → 222
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      TIGR00574
      Location:335 → 844
      dnl1; DNA ligase I, ATP-dependent (dnl1)

    3. XM_015295726.4 → XP_015151212.2  DNA ligase 3 isoform X3

      Conserved Domains (2) summary
      PLN03123
      Location:115 → 222
      PLN03123; poly [ADP-ribose] polymerase; Provisional
      TIGR00574
      Location:335 → 800
      dnl1; DNA ligase I, ATP-dependent (dnl1)

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052591.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      4718210..4733486 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046930044.1 → XP_046786000.1  DNA ligase 3 isoform X1

      UniProtKB/TrEMBL
      A0A8V1ALB9

    2. XM_046930045.1 → XP_046786001.1  DNA ligase 3 isoform X2

      UniProtKB/TrEMBL
      A0A8V1ALB9

    3. XM_046930046.1 → XP_046786002.1  DNA ligase 3 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Molecular Biology Databases
    Research Materials