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    STK10 serine/threonine kinase 10 [ Gallus gallus (chicken) ]

    Gene ID: 416204, updated on 3-Dec-2024

    Summary

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    Symbol
    STK10provided by CGNC
    Full Name
    serine/threonine kinase 10provided by CGNC
    Primary source
    CGNC:2029
    See related
    Ensembl:ENSGALG00010012358
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See STK10 in Genome Data Viewer
    Location:
    chromosome: 13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 13 NC_052544.1 (8420111..8462533)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 13 NC_052585.1 (8425259..8468166)

    Chromosome 13 - NC_052544.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112533432 Neighboring gene ubiquitin domain containing 2 Neighboring gene SH3 and PX domains 2B Neighboring gene neuralized E3 ubiquitin protein ligase 1B Neighboring gene microRNA 6652

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Binding chicken Anx2 is beneficial for infection with infectious bursal disease virus. Ren X, et al. Virus Res, 2015 Dec 2. PMID 26221766
    2. Deficiency of a STE20/PAK family kinase LOK leads to the acceleration of LFA-1 clustering and cell adhesion of activated lymphocytes. Endo J, et al. FEBS Lett, 2000 Feb 25. PMID 10692593
    3. Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue. Walter SA, et al. J Biol Chem, 2003 May 16. PMID 12639966
    4. LOK is a major ERM kinase in resting lymphocytes and regulates cytoskeletal rearrangement through ERM phosphorylation. Belkina NV, et al. Proc Natl Acad Sci U S A, 2009 Mar 24. PMID 19255442, Free PMC Article
    5. Activation segment dimerization: a mechanism for kinase autophosphorylation of non-consensus sites. Pike AC, et al. EMBO J, 2008 Feb 20. PMID 18239682, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    serine/threonine-protein kinase 10
    NP_001292138.2
    XP_046756297.1
    XP_046756299.1
    XP_046782894.1
    XP_046782895.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305209.2 → NP_001292138.2  serine/threonine-protein kinase 10

      Status: VALIDATED

      Source sequence(s)
      JAENSK010000256
      UniProtKB/Swiss-Prot
      F1NBT0
      UniProtKB/TrEMBL
      A0A8V0YHH4
      Related
      ENSGALP00010017223.1, ENSGALT00010029605.1
      Conserved Domains (1) summary
      cd06644
      Location:23 → 314
      STKc_STK10; Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK)

    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052544.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      8420111..8462533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046900341.1 → XP_046756297.1  serine/threonine-protein kinase 10 isoform X1

      UniProtKB/Swiss-Prot
      F1NBT0
      UniProtKB/TrEMBL
      A0A8V0Y934
      Related
      ENSGALP00010017215.1, ENSGALT00010029594.1

    2. XM_046900343.1 → XP_046756299.1  serine/threonine-protein kinase 10 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YM88
      Related
      ENSGALP00010017211.1, ENSGALT00010029590.1

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052585.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      8425259..8468166
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_046926938.1 → XP_046782894.1  serine/threonine-protein kinase 10 isoform X1

      UniProtKB/Swiss-Prot
      F1NBT0

    2. XM_046926939.1 → XP_046782895.1  serine/threonine-protein kinase 10 isoform X2

      UniProtKB/TrEMBL
      A0A8V0YM88
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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    Research Materials