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    PIK3C2B phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta [ Gallus gallus (chicken) ]

    Gene ID: 419822, updated on 17-Aug-2024

    Summary

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    Symbol
    PIK3C2Bprovided by CGNC
    Full Name
    phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 betaprovided by CGNC
    Primary source
    CGNC:51098
    See related
    Ensembl:ENSGALG00010027372
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See PIK3C2B in Genome Data Viewer
    Location:
    chromosome: 26
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 26 NC_052557.1 (1827113..1847293, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 26 NC_052598.1 (1797340..1817520, complement)

    Chromosome 26 - NC_052557.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107055203 Neighboring gene protein phosphatase 1 regulatory subunit 15B Neighboring gene uncharacterized LOC121107614 Neighboring gene transfer RNA lysine (anticodon UUU) Neighboring gene transfer RNA lysine (anticodon UUU)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables 1-phosphatidylinositol-4-phosphate 3-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables phosphatidylinositol binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-3-phosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phosphatidylinositol-mediated signaling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of phosphatidylinositol 3-kinase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta
    Names
    phosphoinositide-3-kinase, class 2, beta polypeptide
    XP_015154583.1
    XP_015154584.1
    XP_040508828.1
    XP_040547410.1
    XP_040547412.1
    XP_040547413.1
    XP_046760160.1
    XP_046760161.1
    XP_046760162.1
    XP_046789124.1
    XP_046789125.1
    XP_046789126.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052557.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      1827113..1847293 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_015299097.4 → XP_015154583.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

      UniProtKB/TrEMBL
      A0A1D5PQ64
      Conserved Domains (6) summary
      cd00895
      Location:981 → 1334
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd07290
      Location:1363 → 1471
      PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:616 → 788
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1499 → 1621
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:807 → 975
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      pfam00794
      Location:358 → 460
      PI3K_rbd; PI3-kinase family, ras-binding domain

    2. XM_046904204.1 → XP_046760160.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

      UniProtKB/TrEMBL
      A0A1D5PQ64

    3. XM_046904206.1 → XP_046760162.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

      UniProtKB/TrEMBL
      A0A1D5PQ64

    4. XM_015299098.4 → XP_015154584.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

      UniProtKB/TrEMBL
      A0A1D5PQ64
      Conserved Domains (6) summary
      cd00895
      Location:981 → 1334
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd07290
      Location:1363 → 1471
      PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:616 → 788
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1499 → 1621
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:807 → 975
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      pfam00794
      Location:358 → 460
      PI3K_rbd; PI3-kinase family, ras-binding domain

    5. XM_046904205.1 → XP_046760161.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

      UniProtKB/TrEMBL
      A0A1D5PQ64
      Related
      ENSGALP00010040635.1, ENSGALT00010066369.1

    6. XM_040652894.2 → XP_040508828.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

      UniProtKB/TrEMBL
      A0A1D5PQ64
      Conserved Domains (6) summary
      cd00895
      Location:981 → 1334
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd07290
      Location:1363 → 1471
      PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:616 → 788
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1499 → 1621
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:807 → 975
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      pfam00794
      Location:358 → 460
      PI3K_rbd; PI3-kinase family, ras-binding domain

    RNA

    1. XR_001470254.4 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052598.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      1797340..1817520 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040691476.2 → XP_040547410.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

      Conserved Domains (6) summary
      cd00895
      Location:981 → 1334
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd07290
      Location:1363 → 1471
      PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:616 → 788
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1499 → 1621
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:807 → 975
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      cl02484
      Location:361 → 458
      PI3K_rbd; PI3-kinase family, ras-binding domain

    2. XM_046933168.1 → XP_046789124.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

    3. XM_046933170.1 → XP_046789126.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

    4. XM_040691479.2 → XP_040547413.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

      Conserved Domains (6) summary
      cd00895
      Location:981 → 1334
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd07290
      Location:1363 → 1471
      PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:616 → 788
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1499 → 1621
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:807 → 975
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      cl02484
      Location:361 → 458
      PI3K_rbd; PI3-kinase family, ras-binding domain

    5. XM_046933169.1 → XP_046789125.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

    6. XM_040691478.2 → XP_040547412.1  phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

      Conserved Domains (6) summary
      cd00895
      Location:981 → 1334
      PI3Kc_C2_beta; Catalytic domain of Class II Phosphoinositide 3-kinase beta
      cd07290
      Location:1363 → 1471
      PX_PI3K_C2_beta; The phosphoinositide binding Phox Homology Domain of the Beta Isoform of Class II Phosphoinositide 3-Kinases
      cd04012
      Location:616 → 788
      C2A_PI3K_class_II; C2 domain first repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd08381
      Location:1499 → 1621
      C2B_PI3K_class_II; C2 domain second repeat present in class II phosphatidylinositol 3-kinases (PI3Ks)
      cd00869
      Location:807 → 975
      PI3Ka_II; Phosphoinositide 3-kinase (PI3K) class II, accessory domain (PIK domain); PIK domain is conserved in all PI3 and PI4-kinases. Its role is unclear but it has been suggested to be involved in substrate presentation. In general, class II PI3-kinases ...
      cl02484
      Location:361 → 458
      PI3K_rbd; PI3-kinase family, ras-binding domain

    RNA

    1. XR_005856144.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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