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    POLE DNA polymerase epsilon, catalytic subunit [ Gallus gallus (chicken) ]

    Gene ID: 416997, updated on 17-Aug-2024

    Summary

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    Symbol
    POLEprovided by CGNC
    Full Name
    DNA polymerase epsilon, catalytic subunitprovided by CGNC
    Primary source
    CGNC:5787
    See related
    Ensembl:ENSGALG00010022162
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See POLE in Genome Data Viewer
    Location:
    chromosome: 15
    Exon count:
    49
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 15 NC_052546.1 (10012471..10032135, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 15 NC_052587.1 (10011883..10031554, complement)

    Chromosome 15 - NC_052546.1Genomic Context describing neighboring genes Neighboring gene phospholipase A2 group III Neighboring gene purinergic receptor P2X 2 Neighboring gene caspase recruitment domain family, member 8 Neighboring gene apoptosis inducing factor, mitochondria associated 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis. Caldwell RB, et al. Genome Biol, 2005. PMID 15642098, Free PMC Article
    2. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    3. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables single-stranded DNA 3'-5' DNA exonuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in DNA replication proofreading IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in base-excision repair, gap-filling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in leading strand elongation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nucleotide-excision repair, DNA gap filling IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of epsilon DNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    DNA polymerase epsilon catalytic subunit A
    Names
    polymerase (DNA directed), epsilon, catalytic subunit
    polymerase (DNA) epsilon, catalytic subunit
    XP_001233985.4
    XP_040504142.1
    XP_040540965.1
    XP_040540966.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052546.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      10012471..10032135 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_001233984.7 → XP_001233985.4  DNA polymerase epsilon catalytic subunit A isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZP62, A0A8V0ZUF2
      Related
      ENSGALP00010032479.1, ENSGALT00010053931.1
      Conserved Domains (2) summary
      cd05779
      Location:262 → 465
      DNA_polB_epsilon_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
      cd05535
      Location:525 → 1147
      POLBc_epsilon; DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed ...

    2. XM_040648208.1 → XP_040504142.1  DNA polymerase epsilon catalytic subunit A isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZNS3, A0A8V0ZP62
      Related
      ENSGALP00010032467.1, ENSGALT00010053915.1
      Conserved Domains (2) summary
      cd05779
      Location:180 → 383
      DNA_polB_epsilon_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
      cd05535
      Location:443 → 1065
      POLBc_epsilon; DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed ...

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052587.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      10011883..10031554 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040685031.2 → XP_040540965.1  DNA polymerase epsilon catalytic subunit A isoform X1

      UniProtKB/TrEMBL
      A0A8V0ZP62
      Conserved Domains (2) summary
      cd05779
      Location:262 → 465
      DNA_polB_epsilon_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
      cd05535
      Location:525 → 1147
      POLBc_epsilon; DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed ...

    2. XM_040685032.1 → XP_040540966.1  DNA polymerase epsilon catalytic subunit A isoform X2

      UniProtKB/TrEMBL
      A0A8V0ZP62
      Conserved Domains (2) summary
      cd05779
      Location:180 → 383
      DNA_polB_epsilon_exo; DEDDy 3'-5' exonuclease domain of eukaryotic DNA polymerase epsilon, a family-B DNA polymerase
      cd05535
      Location:443 → 1065
      POLBc_epsilon; DNA polymerase type-B epsilon subfamily catalytic domain. Three DNA-dependent DNA polymerases type B (alpha, delta, and epsilon) have been identified as essential for nuclear DNA replication in eukaryotes. DNA polymerase (Pol) epsilon has been proposed ...

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001012530.1: Suppressed sequence

      Description
      NM_001012530.1: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    Nucleotide Protein Strain
    Heading Accession and Version

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