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    PLXND1 plexin D1 [ Gallus gallus (chicken) ]

    Gene ID: 416124, updated on 17-Aug-2024

    Summary

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    Symbol
    PLXND1provided by CGNC
    Full Name
    plexin D1provided by CGNC
    Primary source
    CGNC:6425
    See related
    Ensembl:ENSGALG00010019208
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See PLXND1 in Genome Data Viewer
    Location:
    chromosome: 12
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 12 NC_052543.1 (19705759..19772289, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 12 NC_052584.1 (19744007..19810537, complement)

    Chromosome 12 - NC_052543.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107054397 Neighboring gene rhodopsin Neighboring gene H1.8 linker histone Neighboring gene uncharacterized LOC107054398 Neighboring gene transmembrane and coiled-coil domain family 1 Neighboring gene uncharacterized LOC121106672 Neighboring gene uncharacterized LOC107054396

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PlexinD1 is required for proper patterning of the periocular vascular network and for the establishment of corneal avascularity during avian ocular development. Kwiatkowski SC, et al. Dev Biol, 2016 Mar 1. PMID 26783882, Free PMC Article
    2. Transcriptome analysis for the chicken based on 19,626 finished cDNA sequences and 485,337 expressed sequence tags. Hubbard SJ, et al. Genome Res, 2005 Jan. PMID 15590942, Free PMC Article
    3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PlexinD1 is involved in vascular response to antiangiogenic Sema3 signaling that guides the formation of the iris and limbal blood vessels by inhibiting VEGF signaling.
      Title: PlexinD1 is required for proper patterning of the periocular vascular network and for the establishment of corneal avascularity during avian ocular development.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables semaphorin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in semaphorin-plexin signaling pathway involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of semaphorin receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    plexin-D1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052543.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      19705759..19772289 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_414455.7 → XP_414455.4  plexin-D1

      UniProtKB/TrEMBL
      A0A3Q2U1R1, A0A8V0Z9M7
      Related
      ENSGALP00010027639.1, ENSGALT00010046425.1
      Conserved Domains (6) summary
      cd11247
      Location:42 → 543
      Sema_plexin_D1; The Sema domain, a protein interacting module, of Plexin D1
      cd01180
      Location:889 → 977
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:545 → 597
      PSI; Plexin repeat
      pfam08337
      Location:1347 → 1891
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:618 → 695
      TIG_plexin; TIG domain
      cl15674
      Location:979 → 1063
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052584.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      19744007..19810537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040682253.2 → XP_040538187.1  plexin-D1

      UniProtKB/TrEMBL
      A0A3Q2U1R1, A0A8V0Z9M7
      Conserved Domains (6) summary
      cd11247
      Location:42 → 543
      Sema_plexin_D1; The Sema domain, a protein interacting module, of Plexin D1
      cd01180
      Location:889 → 977
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      pfam01437
      Location:545 → 597
      PSI; Plexin repeat
      pfam08337
      Location:1347 → 1891
      Plexin_cytopl; Plexin cytoplasmic RasGAP domain
      pfam17960
      Location:618 → 695
      TIG_plexin; TIG domain
      cl15674
      Location:979 → 1063
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    Nucleotide Protein Strain
    Heading Accession and Version

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