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    clp-3 Calpain catalytic domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 173089, updated on 9-Dec-2024

    Summary

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    Official Symbol
    clp-3
    Official Full Name
    Calpain catalytic domain-containing protein
    Primary source
    WormBase:WBGene00000544
    Locus tag
    CELE_Y47H10A.1
    See related
    AllianceGenome:WB:WBGene00000544
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable calcium-dependent cysteine-type endopeptidase activity. Predicted to be involved in proteolysis. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in autosomal dominant limb-girdle muscular dystrophy; autosomal recessive limb-girdle muscular dystrophy type 2A; hereditary spastic paraplegia 76; muscular dystrophy; and stomach cancer. Orthologous to several human genes including CAPN1 (calpain 1); CAPN11 (calpain 11); and CAPN2 (calpain 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See clp-3 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    11
    Sequence:
    Chromosome: I; NC_003279.8 (12073072..12084225, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene MARVEL domain-containing protein;Secreted protein Neighboring gene Uncharacterized protein Neighboring gene pseudo Neighboring gene F-box associated domain-containing protein Neighboring gene Decapping nuclease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans. Syntichaki P, et al. Nature, 2002 Oct 31. PMID 12410314
    2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
    3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
    4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables calcium-dependent cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium-dependent cysteine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables cysteine-type peptidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in proteolysis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Calpain catalytic domain-containing protein
    NP_493052.3
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      12073072..12084225 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_060651.7 → NP_493052.3  Calpain catalytic domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9U2B2
      Conserved Domains (3) summary
      COG5271
      Location:5 → 136
      MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
      cd00044
      Location:254 → 559
      CysPc; Calpains, domains IIa, IIb; calcium-dependent cytoplasmic cysteine proteinases, papain-like. Functions in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction.
      cd00214
      Location:582 → 732
      Calpain_III; Calpain, subdomain III. Calpains are calcium-activated cytoplasmic cysteine proteinases, participate in cytoskeletal remodeling processes, cell differentiation, apoptosis and signal transduction. Catalytic domain and the two calmodulin-like domains are ...
    Nucleotide Protein
    Heading Accession and Version

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