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    PARK2 parkin RBR E3 ubiquitin protein ligase [ Gallus gallus (chicken) ]

    Gene ID: 421577, updated on 17-Aug-2024

    Summary

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    Symbol
    PARK2provided by CGNC
    Full Name
    parkin RBR E3 ubiquitin protein ligaseprovided by CGNC
    Primary source
    CGNC:8787
    See related
    Ensembl:ENSGALG00010006183
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Also known as
    PRKN
    Orthologs
    human mouse all
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    Genomic context

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    See PARK2 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (44160574..44841447)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (44067431..44746459)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121110378 Neighboring gene PARK2 coregulated Neighboring gene 1-acylglycerol-3-phosphate O-acyltransferase 4 Neighboring gene uncharacterized LOC107053028 Neighboring gene mitogen-activated protein kinase kinase kinase 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PARK2 Microdeletion or Duplications Have Been Implicated in Different Neurological Disorders Including Early Onset Parkinson Disease. Ahmad A, et al. Genes (Basel), 2023 Feb 27. PMID 36980871, Free PMC Article
    2. Role of mitochondrial dysfunction and PINK1/Parkin-mediated mitophagy in Cd-induced hepatic lipid accumulation in chicken embryos. Chen D, et al. Life Sci, 2021 Nov 1. PMID 34478761
    3. FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells. Pentzold C, et al. Nucleic Acids Res, 2018 Feb 16. PMID 29253234, Free PMC Article
    4. Parkin elimination of mitochondria is important for maintenance of lens epithelial cell ROS levels and survival upon oxidative stress exposure. Brennan L, et al. Biochim Biophys Acta Mol Basis Dis, 2017 Jan. PMID 27702626, Free PMC Article
    5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PARK2 Microdeletion or Duplications Have Been Implicated in Different Neurological Disorders Including Early Onset Parkinson Disease.
      Title: PARK2 Microdeletion or Duplications Have Been Implicated in Different Neurological Disorders Including Early Onset Parkinson Disease.
    2. Role of mitochondrial dysfunction and PINK1/Parkin-mediated mitophagy in Cd-induced hepatic lipid accumulation in chicken embryos.
      Title: Role of mitochondrial dysfunction and PINK1/Parkin-mediated mitophagy in Cd-induced hepatic lipid accumulation in chicken embryos.
    3. FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells, with high mutation rates at the common chromosomal fragile sites gene PARK2.
      Title: FANCD2 binding identifies conserved fragile sites at large transcribed genes in avian cells.
    4. Increased levels of Parkin are detected in lens epithelial cells exposed to H2O2-oxidative stress. Parkin translocates to mitochondria of lens epithelial cells upon H2O2-oxidative stress exposure. Parkin ubiquitin ligase activity is required for clearance of damaged mitochondria in lens epithelial cells exposed to H2O2-oxidative stress.
      Title: Parkin elimination of mitochondria is important for maintenance of lens epithelial cell ROS levels and survival upon oxidative stress exposure.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ubiquitin conjugating enzyme binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in autophagy of mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein polyubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cellular response to oxidative stress IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of mitochondrion organization IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase parkin
    Names
    Parkinson disease (autosomal recessive, juvenile) 2, parkin
    parkinson protein 2, E3 ubiquitin protein ligase (parkin)
    XP_040523861.1
    XP_040523862.1
    XP_040554084.1
    XP_046770560.1
    XP_046795148.1
    XP_419615.4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      44160574..44841447
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_419615.8 → XP_419615.4  E3 ubiquitin-protein ligase parkin isoform X1

      UniProtKB/TrEMBL
      A0A8V0XRV2, A0A8V0XXC0
      Related
      ENSGALP00010008691.1, ENSGALT00010014745.1
      Conserved Domains (4) summary
      smart00647
      Location:311 → 373
      IBR; In Between Ring fingers
      cd16627
      Location:234 → 292
      RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
      cd01798
      Location:3 → 71
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      cl19760
      Location:400 → 456
      IBR; IBR domain, a half RING-finger domain

    2. XM_040698150.2 → XP_040554084.1  E3 ubiquitin-protein ligase parkin isoform X3

      UniProtKB/TrEMBL
      A0A8V0XRV2
      Conserved Domains (4) summary
      smart00647
      Location:310 → 372
      IBR; In Between Ring fingers
      cd16627
      Location:234 → 292
      RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
      cd01798
      Location:3 → 71
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      cl19760
      Location:399 → 455
      IBR; IBR domain, a half RING-finger domain

    3. XM_046939192.1 → XP_046795148.1  E3 ubiquitin-protein ligase parkin isoform X2

    RNA

    1. XR_005858705.2 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      44067431..44746459
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040667928.2 → XP_040523862.1  E3 ubiquitin-protein ligase parkin isoform X1

      UniProtKB/TrEMBL
      A0A8V0XRV2
      Conserved Domains (4) summary
      smart00647
      Location:310 → 372
      IBR; In Between Ring fingers
      cd16627
      Location:234 → 292
      RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
      cd01798
      Location:3 → 71
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      cl19760
      Location:399 → 455
      IBR; IBR domain, a half RING-finger domain

    2. XM_040667927.1 → XP_040523861.1  E3 ubiquitin-protein ligase parkin isoform X4

      UniProtKB/TrEMBL
      A0A8V0XRV2
      Conserved Domains (4) summary
      smart00647
      Location:310 → 372
      IBR; In Between Ring fingers
      cd16627
      Location:234 → 292
      RING-HC_RBR_parkin; RING finger, HC subclass, found in parkin and similar proteins
      cd01798
      Location:4 → 71
      Ubl_parkin; ubiquitin-like (Ubl) domain found in parkin and similar proteins
      cl19760
      Location:399 → 455
      IBR; IBR domain, a half RING-finger domain

    3. XM_046914604.1 → XP_046770560.1  E3 ubiquitin-protein ligase parkin isoform X2

    RNA

    1. XR_005848553.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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