ccz-1 Vacuolar fusion protein CCZ1 homolog [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: ccz-1
Official Full Name: Vacuolar fusion protein CCZ1 homolog
Primary source: WormBase:WBGene00010283
Locus tag: CELE_F58G11.6
See related: AllianceGenome:WB:WBGene00010283
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Involved in lipid droplet disassembly and phagolysosome assembly involved in apoptotic cell clearance. Located in phagocytic vesicle. Used to study Hermansky-Pudlak syndrome. Orthologous to human CCZ1B (CCZ1 homolog B, vacuolar protein trafficking and biogenesis associated) and CCZ1 (CCZ1 homolog, vacuolar protein trafficking and biogenesis associated). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See ccz-1 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 7

Sequence:: Chromosome: V; NC_003283.11 (13678875..13681539)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data identify SAND-1 (Mon1) and CCZ-1 (Ccz1) as critical and evolutionarily conserved components regulating the processing of ingested apoptotic cell corpses
Title: Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells.
cpl-1, ccz-1, and asm-3 are genes required for the processing of lipid-containing droplets in C. elegans embryos
Title: Genetics of Lipid-Storage Management in Caenorhabditis elegans Embryos.
CCZ-1 and the HOPS complex are essential for the biogenesis of gut granules, cell type-specific, lysosome-related organelles that coexist with conventional lysosomes in Caenorhabditis elegans intestinal cells, independent of RAB-7 and SAND-1.
Title: Caenorhabditis elegans HOPS and CCZ-1 mediate trafficking to lysosome-related organelles independently of RAB-7 and SAND-1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F58G11.6 (e-PCR)
- UniSTS:314537

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in lipid droplet disassembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in lysosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagolysosome assembly involved in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phagosome maturation involved in apoptotic cell clearance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vesicle-mediated transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle-mediated transport	IEA Inferred from Electronic Annotation more info
involved_in vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Mon1-Ccz1 complex	IEA Inferred from Electronic Annotation more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in phagocytic vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Vacuolar fusion protein CCZ1 homolog

NP_506387.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

13678875..13681539

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_073986.4 → NP_506387.1 Vacuolar fusion protein CCZ1 homolog [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506387.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9XVL8

Conserved Domains (1) summary

pfam08217
Location:34 → 526

DUF1712; Fungal domain of unknown function (DUF1712)