EDN1 endothelin 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: EDN1provided by CGNC
Full Name: endothelin 1provided by CGNC
Primary source: CGNC:9661
Gene type: protein coding
RefSeq status: MODEL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	2	NC_052533.1 (62406640..62411539, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	2	NC_052574.1 (62355336..62360235, complement)

Chromosome 2 - NC_052533.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Differences in the expression of 5 proteins, including endothelin 1 and platelet-derived growth factor, in the lungs of chickens with or without pulmonary hypertension are reported.
Title: Endothelin 1, its endothelin type A receptor, connective tissue growth factor, platelet-derived growth factor, and adrenomedullin expression in lungs of pulmonary hypertensive and nonhypertensive chickens.
mRNA expression of genes of the TGF beta family and endothelin 1 in lung samples from 4-week-old chickens with pulmonary hypertension, were determined.
Title: Over, and underexpression of endothelin 1 and TGF-beta family ligands and receptors in lung tissue of broilers with pulmonary hypertension.
Data suggest that selenium (Se; a dietary factor) down-regulates expression of endothelin-1 and endothelin A receptor (but not endothelin B receptor) in Se-deficient pulmonary microvascular endothelial cells from chick embryos.
Title: Effects of selenium supplementation on expression of endothelin-1 and its receptors in pulmonary microvascular endothelial cells from chick embryos.
Endothelin-1-induced proliferation of chicken pulmonary artery SMCs (PA-SMCs) was concomitant with increased pro- and active matrix metalloproteinase (MMP)-2 production. However, PA-SMC proliferation was inhibited by two MMP inhibitors.
Title: Involvement of matrix metalloproteinase-2 in medial hypertrophy of pulmonary arterioles in broiler chickens with pulmonary arterial hypertension.
It is concluded that endothelin (ET) increase and ET receptor genes decrease are involved in the heart dysfunction of chickens with developmental pulmonary hypertension.
Title: Gene expression of endothelin-1 and its receptors in the heart of broiler chickens with T(3)-induced pulmonary hypertension.
Exposure to low-dose trichloroethylene alters endothelin-1 gene expression and function in the developing chick heart.
Title: Exposure to low-dose trichloroethylene alters shear stress gene expression and function in the developing chick heart.
Cardiovascular malformations after venous clipping arise from a combination of hemodynamic changes/altered expression of endothelin-1 pathway components.
Title: The endothelin-1 pathway and the development of cardiovascular defects in the haemodynamically challenged chicken embryo.
in the embryonic cardiovascular system, KLF-2 is expressed in regions of highest shear stress, and ET-1 and NOS-3 expression is related to shear stress
Title: Development-related changes in the expression of shear stress responsive genes KLF-2, ET-1, and NOS-3 in the developing cardiovascular system of chicken embryos.

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General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables endothelin A receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables endothelin B receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables hormone activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular calcium ion homeostasis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of prostaglandin-endoperoxide synthase activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of systemic arterial blood pressure by endothelin	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of vasoconstriction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in vein smooth muscle contraction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: endothelin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

62406640..62411539 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_418943.6 → XP_418943.2 endothelin-1

UniProtKB/TrEMBL

A0A4P9IUV3

Conserved Domains (2) summary

smart00272
Location:102 → 123

END; Endothelin

cl27714
Location:46 → 70

Endothelin; Endothelin family

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

62355336..62360235 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040664613.2 → XP_040520547.1 endothelin-1

UniProtKB/TrEMBL

A0A4P9IUV3

Conserved Domains (2) summary

smart00272
Location:102 → 123

END; Endothelin

cl27714
Location:46 → 70

Endothelin; Endothelin family