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    SOS1 SOS Ras/Rac guanine nucleotide exchange factor 1 [ Gallus gallus (chicken) ]

    Gene ID: 431192, updated on 17-Aug-2024

    Summary

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    Official Symbol
    SOS1provided by CGNC
    Official Full Name
    SOS Ras/Rac guanine nucleotide exchange factor 1provided by CGNC
    Primary source
    CGNC:54157
    See related
    Ensembl:ENSGALG00010017280
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Gallus gallus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
    Orthologs
    human mouse all
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    Genomic context

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    See SOS1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 3 NC_052534.1 (16291725..16350377, complement)
    106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 3 NC_052575.1 (16206678..16265352, complement)

    Chromosome 3 - NC_052534.1Genomic Context describing neighboring genes Neighboring gene DExH-box helicase 57 Neighboring gene Rho guanine nucleotide exchange factor 33 Neighboring gene MORN repeat containing 2 Neighboring gene mitogen-activated protein kinase kinase kinase kinase 3 Neighboring gene uncharacterized LOC121110398 Neighboring gene THUMP domain containing 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
    2. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein heterodimerization activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Ras protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    son of sevenless homolog 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Genomic

    1. NC_052534.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

      Range
      16291725..16350377 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_003640931.6 → XP_003640979.3  son of sevenless homolog 1

      UniProtKB/TrEMBL
      A0A1D5PEZ2, A0A8V0YTL6
      Related
      ENSGALP00010024390.1, ENSGALT00010041698.1
      Conserved Domains (6) summary
      PTZ00449
      Location:1018 → 1305
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      smart00229
      Location:597 → 741
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:776 → 1015
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00160
      Location:201 → 388
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01261
      Location:439 → 545
      PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
      pfam00125
      Location:70 → 169
      Histone; Core histone H2A/H2B/H3/H4

    RNA

    1. XR_005858804.2 RNA Sequence

    Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Genomic

    1. NC_052575.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

      Range
      16206678..16265352 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_040668101.2 → XP_040524035.1  son of sevenless homolog 1

      UniProtKB/TrEMBL
      A0A1D5PEZ2, A0A8V0YTL6
      Conserved Domains (6) summary
      PTZ00449
      Location:1018 → 1305
      PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
      smart00229
      Location:597 → 741
      RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
      cd00155
      Location:776 → 1015
      RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
      cd00160
      Location:201 → 388
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd01261
      Location:439 → 545
      PH_SOS; Son of Sevenless (SOS) Pleckstrin homology (PH) domain
      pfam00125
      Location:70 → 169
      Histone; Core histone H2A/H2B/H3/H4

    RNA

    1. XR_005848606.2 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version

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