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    fxyd6l FXYD domain containing ion transport regulator 6 like [ Danio rerio (zebrafish) ]

    Gene ID: 566443, updated on 4-Jan-2025

    Summary

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    Official Symbol
    fxyd6lprovided by ZNC
    Official Full Name
    FXYD domain containing ion transport regulator 6 likeprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-071205-8
    See related
    Ensembl:ENSDARG00000097057 AllianceGenome:ZFIN:ZDB-GENE-071205-8
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Summary
    Predicted to enable ion channel regulator activity. Predicted to act upstream of or within monoatomic ion transport and regulation of monoatomic ion transport. Predicted to be located in membrane. Is expressed in otic vesicle. Orthologous to human FXYD6P3 (FXYD domain containing ion transport regulator 6 pseudogene 3). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    all
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    Genomic context

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    See fxyd6l in Genome Data Viewer
    Location:
    chromosome: 16
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 16 NC_007127.7 (24601140..24642866, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 16 NC_007127.6 (24686108..24727834, complement)

    Chromosome 16 - NC_007127.7Genomic Context describing neighboring genes Neighboring gene si:ch211-79k12.2 Neighboring gene nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta Neighboring gene FXYD domain containing ion transport regulator 7 Neighboring gene si:dkey-56f14.7 Neighboring gene paraoxonase 1 Neighboring gene paraoxonase 3, tandem duplicate 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Ion channel gene expression in the inner ear. Gabashvili IS, et al. J Assoc Res Otolaryngol, 2007 Sep. PMID 17541769, Free PMC Article
    2. Identification of zebrafish Fxyd11a protein that is highly expressed in ion-transporting epithelium of the gill and skin and its possible role in ion homeostasis. Saito K, et al. Front Physiol, 2010. PMID 21423371, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables ion channel regulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    FXYD domain containing ion transport regulator 6 like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001201417.1 → NP_001188346.1  FXYD domain containing ion transport regulator 6 like isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      CR848666, EH472089, EH590513
      UniProtKB/TrEMBL
      A0A8M1NYK1, A0A8M2B4G0
      Conserved Domains (1) summary
      pfam02038
      Location:35 → 79
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    2. NM_001201418.1 → NP_001188347.1  FXYD domain containing ion transport regulator 6 like isoform 2

      See identical proteins and their annotated locations for NP_001188347.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an upstream start codon compared to variant 1. The resulting protein (isoform 2) is the same length as isoform 1 but has a distinct N-terminus. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      CR848666, EH472089, EH553110
      UniProtKB/TrEMBL
      A0A8M1P2F3, A0A8M9PD66
      Conserved Domains (1) summary
      pfam02038
      Location:35 → 79
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    3. NM_001201419.1 → NP_001188348.1  FXYD domain containing ion transport regulator 6 like isoform 2

      See identical proteins and their annotated locations for NP_001188348.1

      Status: VALIDATED

      Description
      Transcript Variant: Transcript Variant: This variant (3) has multiple differences compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at an upstream start codon compared to variant 1. The resulting protein (isoform 2) is the same length as isoform 1 but has a distinct N-terminus. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      BM534466, CR848666, EH472089
      UniProtKB/TrEMBL
      A0A8M1P2F3, A0A8M9PD66
      Conserved Domains (1) summary
      pfam02038
      Location:35 → 79
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    4. NM_001201420.1 → NP_001188349.1  FXYD domain containing ion transport regulator 6 like isoform 3 precursor

      See identical proteins and their annotated locations for NP_001188349.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks an exon in the 5' coding region but maintains the reading frame compared to variant 1. The resulting protein (isoform 3) is shorter than isoform 1 but has the same N- and C-termini.
      Source sequence(s)
      CR848666, EH442222, EH472089
      UniProtKB/TrEMBL
      A0A8M1NYW9, A0A8M2B4G0, X1WE12
      Related
      ENSDARP00000127704.1, ENSDART00000155983.3
      Conserved Domains (1) summary
      pfam02038
      Location:26 → 70
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007127.7 Reference GRCz11 Primary Assembly

      Range
      24601140..24642866 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021466730.2 → XP_021322405.1  FXYD domain containing ion transport regulator 6 like isoform X2

      UniProtKB/TrEMBL
      A0A8M9PD66, A0A8M9PMJ5
      Conserved Domains (1) summary
      pfam02038
      Location:26 → 62
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family

    2. XM_021466727.2 → XP_021322402.1  FXYD domain containing ion transport regulator 6 like isoform X1

      UniProtKB/TrEMBL
      A0A8M9NZC2, A0A8M9PJK2
      Conserved Domains (1) summary
      pfam02038
      Location:35 → 71
      ATP1G1_PLM_MAT8; ATP1G1/PLM/MAT8 family
    Nucleotide Protein Strain
    Heading Accession and Version

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