mes-6 Polycomb protein mes-6 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: mes-6
Official Full Name: Polycomb protein mes-6
Primary source: WormBase:WBGene00003224
Locus tag: CELE_C09G4.5
See related: AllianceGenome:WB:WBGene00003224
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to contribute to nucleosome binding activity. Involved in regulation of gene expression. Part of PcG protein complex and nucleosome. Is expressed in Z2; Z3; intestinal cell; oocyte; and reproductive system. Orthologous to human EED (embryonic ectoderm development). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See mes-6 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (8511284..8513469)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mes-6 represses Hox expression, causing anteroposterior transformations and disrupts Hox-dependent neuroblast migration.
Title: Polycomb group regulation of Hox gene expression in C. elegans.
mes-6 mutants suppress mab-3.
Title: Finally, worm polycomb-like genes meet Hox regulation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C09G4.4 (e-PCR)
- UniSTS:320777

C09G4.5 (e-PCR)
- UniSTS:313521

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
contributes_to nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ESC/E(Z) complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PcG protein complex	IPI Inferred from Physical Interaction more info	PubMed
part_of nucleosome	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Polycomb protein mes-6

NP_001370414.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8511284..8513469

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001383148.2 → NP_001370414.1 Polycomb protein mes-6 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O16187, Q9GYS1

Conserved Domains (2) summary

sd00039
Location:152 → 192

7WD40; WD40 repeat [structural motif]

cl29593
Location:120 → 433

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...