tatn-1 Tyrosine aminotransferase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tatn-1
Official Full Name: Tyrosine aminotransferase
Primary source: WormBase:WBGene00009628
Locus tag: CELE_F42D1.2
See related: AllianceGenome:WB:WBGene00009628
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable L-tyrosine-2-oxoglutarate transaminase activity. Involved in dauer entry. Is expressed in several structures, including body wall musculature; hypodermis; intestine; muscle cell; and pharynx. Human ortholog(s) of this gene implicated in tyrosinemia and tyrosinemia type II. Orthologous to human TAT (tyrosine aminotransferase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See tatn-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 3

Sequence:: Chromosome: X; NC_003284.9 (14791008..14792984)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

tatn-1 mutant worms exhibited delayed development, marked reduction in fertility, and shortened lifespan when exposed to m-tyrosine
Title: Tyrosine aminotransferase is involved in the oxidative stress response by metabolizing meta-tyrosine in Caenorhabditis elegans.
We also find that the controlled metabolism of tyrosine by tatn-1 may function normally in dauer formation because the expression of the TATN-1 protein is regulated both by daf-2/IGFR signaling
Title: TATN-1 mutations reveal a novel role for tyrosine as a metabolic signal that influences developmental decisions and longevity in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS6-209 (e-PCR)
- UniSTS:242594

F42D1.2 (e-PCR)
- UniSTS:321465

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables L-tyrosine-2-oxoglutarate transaminase activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-tyrosine-2-oxoglutarate transaminase activity	IEA Inferred from Electronic Annotation more info
enables pyridoxal phosphate binding	IEA Inferred from Electronic Annotation more info
enables transaminase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in L-phenylalanine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-phenylalanine catabolic process	IEA Inferred from Electronic Annotation more info
involved_in amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in aromatic amino acid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in dauer entry	IGI Inferred from Genetic Interaction more info	PubMed
involved_in tyrosine catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in tyrosine catabolic process	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Tyrosine aminotransferase

NP_510454.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

14791008..14792984

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_078053.8 → NP_510454.1 Tyrosine aminotransferase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_510454.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93703

Conserved Domains (1) summary

TIGR01264
Location:43 → 442

tyr_amTase_E; tyrosine aminotransferase, eukaryotic