usp-14 Ubiquitin carboxyl-terminal hydrolase 14 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: usp-14
Official Full Name: Ubiquitin carboxyl-terminal hydrolase 14
Primary source: WormBase:WBGene00006856
Locus tag: CELE_C13B4.2
See related: AllianceGenome:WB:WBGene00006856
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable cysteine-type deubiquitinase activity and proteasome binding activity. Predicted to be involved in negative regulation of ERAD pathway. Predicted to be part of proteasome complex. Is expressed in germ line. Orthologous to human USP14 (ubiquitin specific peptidase 14). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See usp-14 in Genome Data Viewer

Location:: chromosome: II

Exon count:: 4

Sequence:: Chromosome: II; NC_003280.10 (14485624..14488688, complement)

Chromosome II - NC_003280.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003280.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C13B4.2 (e-PCR)
- UniSTS:313540

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables cysteine-type deubiquitinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cysteine-type deubiquitinase activity	IEA Inferred from Electronic Annotation more info
enables cysteine-type peptidase activity	IEA Inferred from Electronic Annotation more info
enables proteasome binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in negative regulation of ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process	IEA Inferred from Electronic Annotation more info
involved_in protein deubiquitination	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of proteasome complex	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Ubiquitin carboxyl-terminal hydrolase 14

NP_497006.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003280.10 Reference assembly

Range

14485624..14488688 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_064605.11 → NP_497006.1 Ubiquitin carboxyl-terminal hydrolase 14 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_497006.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O45248, Q17361

Conserved Domains (4) summary

smart00213
Location:4 → 71

UBQ; Ubiquitin homologues

cd02657
Location:103 → 456

Peptidase_C19A; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl ...

pfam00443
Location:101 → 455

UCH; Ubiquitin carboxyl-terminal hydrolase

cl00155
Location:1 → 71

UBQ; Ubiquitin-like proteins