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    smurf1 SMAD specific E3 ubiquitin protein ligase 1 [ Danio rerio (zebrafish) ]

    Gene ID: 321695, updated on 26-Jan-2025

    Summary

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    Official Symbol
    smurf1provided by ZNC
    Official Full Name
    SMAD specific E3 ubiquitin protein ligase 1provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2744
    See related
    Ensembl:ENSDARG00000016086 AllianceGenome:ZFIN:ZDB-GENE-040426-2744
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    wwp1; zgc:66401; wu:fb30b12
    Summary
    Predicted to enable SMAD binding activity and ubiquitin protein ligase activity. Predicted to be involved in negative regulation of BMP signaling pathway and proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to act upstream of or within ubiquitin-dependent protein catabolic process. Predicted to be active in cytoplasm. Is expressed in alar plate midbrain region; axis; midbrain; neural plate; and notochord. Orthologous to human SMURF1 (SMAD specific E3 ubiquitin protein ligase 1). [provided by Alliance of Genome Resources, Jan 2025]
    Orthologs
    human mouse all
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    Genomic context

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    See smurf1 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCz11 (GCF_000002035.6) 3 NC_007114.7 (40690212..40768575, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 3 NC_007114.6 (40548354..40626753, complement)

    Chromosome 3 - NC_007114.7Genomic Context describing neighboring genes Neighboring gene ring finger protein 216 Neighboring gene urotensin-2 receptor 5 Neighboring gene uncharacterized LOC137490719 Neighboring gene actin related protein 2/3 complex, subunit 1A

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Smurf1 regulates neural patterning and folding in Xenopus embryos by antagonizing the BMP/Smad1 pathway. Alexandrova EM, et al. Dev Biol, 2006 Nov 15. PMID 16973150, Free PMC Article
    2. VprBP mitigates TGF-β and Activin signaling by promoting Smurf1-mediated type I receptor degradation. Li Y, et al. J Mol Cell Biol, 2020 Feb 20. PMID 31291647, Free PMC Article
    3. Itch is required for lateral line development in zebrafish. Angers A, et al. PLoS One, 2014. PMID 25369329, Free PMC Article
    4. Trb3 regulates LR axis formation in zebrafish embryos. Anuppalle M, et al. Mol Cells, 2013 Dec. PMID 24292884, Free PMC Article
    5. Transcriptomic Characterization of Key Factors and Signaling Pathways for the Regeneration of Partially Hepatectomized Liver in Zebrafish. Song G, et al. Int J Mol Sci, 2024 Jun 29. PMID 39000319, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables SMAD binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of BMP signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase SMURF1
    Names
    E3 ubiquitin ligase SMURF1
    WW domain containing E3 ubiquitin protein ligase 1
    smad ubiquitination regulatory factor 1
    NP_001001943.1
    XP_005164172.1
    XP_021325044.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001001943.1 → NP_001001943.1  E3 ubiquitin-protein ligase SMURF1

      See identical proteins and their annotated locations for NP_001001943.1

      Status: PROVISIONAL

      Source sequence(s)
      BC059201
      UniProtKB/TrEMBL
      Q6PCR3
      Related
      ENSDARP00000003721.7, ENSDART00000004923.9
      Conserved Domains (4) summary
      cd08382
      Location:14 → 138
      C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
      smart00456
      Location:234 → 266
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:397 → 728
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:373 → 728
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007114.7 Reference GRCz11 Primary Assembly

      Range
      40690212..40768575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021469369.2 → XP_021325044.1  E3 ubiquitin-protein ligase SMURF1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9PJN2
      Conserved Domains (3) summary
      cd08382
      Location:14 → 138
      C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
      smart00456
      Location:234 → 266
      WW; Domain with 2 conserved Trp (W) residues
      cd00078
      Location:324 → 679
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...

    2. XM_005164115.5 → XP_005164172.1  E3 ubiquitin-protein ligase SMURF1 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BBE4
      Conserved Domains (4) summary
      cd08382
      Location:14 → 138
      C2_Smurf-like; C2 domain present in Smad ubiquitination-related factor (Smurf)-like proteins
      smart00456
      Location:280 → 312
      WW; Domain with 2 conserved Trp (W) residues
      smart00119
      Location:397 → 725
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:373 → 725
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
    Nucleotide Protein Strain
    Heading Accession and Version

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