sams-1 putative S-adenosylmethionine synthase 1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sams-1
Official Full Name: putative S-adenosylmethionine synthase 1
Primary source: WormBase:WBGene00008205
Locus tag: CELE_C49F5.1
See related: AllianceGenome:WB:WBGene00008205
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and negative regulation of lipid storage. Predicted to be active in cytosol. Is expressed in body wall musculature; dorsal nerve cord; and ventral nerve cord. Used to study lipid metabolism disorder. Human ortholog(s) of this gene implicated in hypermethioninemia and lung cancer. Orthologous to human MAT1A (methionine adenosyltransferase 1A) and MAT2A (methionine adenosyltransferase 2A). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See sams-1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 5

Sequence:: Chromosome: X; NC_003284.9 (11965962..11969893)

Chromosome X - NC_003284.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003284.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

blmp-1 is necessary for controlling histone methylation level in daf-7 mutants, suggesting BLMP-1 regulates the expression of SAMS-1, which in turn may regulate histone methylation and dauer formation.Our results reveal a new interaction between BLMP-1/BLIMP-1 and LIN-40/MTA1, as well as potential epigenetic downstream pathways
Title: BLIMP-1/BLMP-1 and Metastasis-Associated Protein Regulate Stress Resistant Development in Caenorhabditis elegans.
SAMS-1 and PMT-1 were shown to contribute to the homoeostasis of TG and PC levels in C. elegans, which would provide an important survival strategy under harsh environmental conditions.
Title: Contribution of sams-1 and pmt-1 to lipid homoeostasis in adult Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C49F5.1 (e-PCR)
- UniSTS:309342

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methionine adenosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine adenosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methionine adenosyltransferase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in S-adenosylmethionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in S-adenosylmethionine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of lipid storage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: putative S-adenosylmethionine synthase 1

NP_001366882.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003284.9 Reference assembly

Range

11965962..11969893

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001381113.3 → NP_001366882.1 putative S-adenosylmethionine synthase 1 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

O17680

Conserved Domains (1) summary

cd18079
Location:6 → 378

S-AdoMet_synt; S-adenosylmethionine synthetase