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    tcer-1 Transcription elongation regulator 1;WW domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 174150, updated on 9-Dec-2024

    Summary

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    Official Symbol
    tcer-1
    Official Full Name
    Transcription elongation regulator 1;WW domain-containing protein
    Primary source
    WormBase:WBGene00022855
    Locus tag
    CELE_ZK1127.9
    See related
    AllianceGenome:WB:WBGene00022855
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase binding activity and transcription coregulator activity. Located in nuclear periphery. Is expressed in several structures, including germ cell; gonad; hypodermal cell; intestinal cell; and somatic cell. Orthologous to several human genes including TCERG1 (transcription elongation regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See tcer-1 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    8
    Sequence:
    Chromosome: II; NC_003280.10 (7045874..7050071, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene DNA topoisomerase-like protein cin-4 Neighboring gene pseudo Neighboring gene putative RNA 3'-terminal phosphate cyclase-like protein Neighboring gene TIGR04255 family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans. Ghazi A, et al. PLoS Genet, 2009 Sep. PMID 19749979, Free PMC Article
    2. The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity. Amrit FRG, et al. Nat Commun, 2019 Jul 17. PMID 31316054, Free PMC Article
    3. DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans. Amrit FR, et al. PLoS Genet, 2016 Feb. PMID 26862916, Free PMC Article
    4. The Gln-Ala repeat transcriptional activator CA150 interacts with huntingtin: neuropathologic and genetic evidence for a role in Huntington's disease pathogenesis. Holbert S, et al. Proc Natl Acad Sci U S A, 2001 Feb 13. PMID 11172033, Free PMC Article
    5. The Caenorhabditis elegans LET-418/Mi2 plays a conserved role in lifespan regulation. De Vaux V, et al. Aging Cell, 2013 Dec. PMID 23815345

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Study data establish key roles for TCER-1, the Caenorhabditis elegans homolog of human transcription elongation and splicing factor, TCERG1, in coordinating immunity, longevity and fertility, and reveal mechanisms that distinguish length of life from functional aspects of aging.
      Title: The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity.
    2. two conserved transcription regulators essential for the longevity of germline-less adults, DAF-16/FOXO3A and TCER-1/TCERG1, concurrently enhance the expression of multiple genes involved in lipid synthesis and breakdown and promote longevity.
      Title: DAF-16 and TCER-1 Facilitate Adaptation to Germline Loss by Restoring Lipid Homeostasis and Repressing Reproductive Physiology in C. elegans.
    3. TCER-1 is required for loss of the germ cells to increase C. elegans' lifespan.
      Title: A transcription elongation factor that links signals from the reproductive system to lifespan extension in Caenorhabditis elegans.
    4. PUF-8 and TCER-1 are essential for normal levels of multiple mRNAs in the C. elegans germline.
      Title: PUF-8 and TCER-1 are essential for normal levels of multiple mRNAs in the C. elegans germline.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA polymerase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nuclear periphery IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Transcription elongation regulator 1;WW domain-containing protein
    NP_001368025.1
    • Confirmed by transcript evidence
    NP_001370832.1
    • Confirmed by transcript evidence
    NP_001380059.1
    • Confirmed by transcript evidence
    NP_001380060.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      7045874..7050071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001383878.2 → NP_001370832.1  WW domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95PX7
      Conserved Domains (3) summary
      smart00456
      Location:168 → 195
      WW; Domain with 2 conserved Trp (W) residues
      COG5104
      Location:235 → 820
      PRP40; Splicing factor [RNA processing and modification]
      pfam01846
      Location:834 → 891
      FF; FF domain

    2. NM_001381486.2 → NP_001368025.1  WW domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95PX8
      Conserved Domains (3) summary
      smart00456
      Location:159 → 186
      WW; Domain with 2 conserved Trp (W) residues
      COG5104
      Location:226 → 811
      PRP40; Splicing factor [RNA processing and modification]
      pfam01846
      Location:825 → 882
      FF; FF domain

    3. NM_001393111.1 → NP_001380059.1  Transcription elongation regulator 1 [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95PX9
      Conserved Domains (2) summary
      smart00441
      Location:549 → 606
      FF; Contains two conserved F residues
      COG5104
      Location:14 → 563
      PRP40; Splicing factor [RNA processing and modification]

    4. NM_001393112.1 → NP_001380060.1  WW domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86MN9
      Conserved Domains (1) summary
      smart00456
      Location:159 → 186
      WW; Domain with 2 conserved Trp (W) residues
    Nucleotide Protein
    Heading Accession and Version

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