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    lgg-3 Ubiquitin-like protein atg-12 [ Caenorhabditis elegans ]

    Gene ID: 175793, updated on 9-Dec-2024

    Summary

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    Official Symbol
    lgg-3
    Official Full Name
    Ubiquitin-like protein atg-12
    Primary source
    WormBase:WBGene00002982
    Locus tag
    CELE_B0336.8
    See related
    AllianceGenome:WB:WBGene00002982
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein tag activity. Predicted to contribute to Atg8-family ligase activity. Involved in cellular response to toxic substance; determination of adult lifespan; and xenophagy. Acts upstream of or within with a positive effect on plasma membrane repair. Located in autophagosome membrane. Orthologous to human ATG12 (autophagy related 12). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See lgg-3 in Genome Data Viewer
    Location:
    chromosome: III
    Exon count:
    3
    Sequence:
    Chromosome: III; NC_003281.10 (5697494..5698013, complement)

    Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene ARF7 effector protein C-terminal domain-containing protein Neighboring gene Transcription initiation factor IIA small chain homolog Neighboring gene THAP-type domain-containing protein Neighboring gene RGS domain-containing protein;Regulator of G-protein signaling rgs-5 Neighboring gene Protein SWAP;SURP motif domain-containing protein;Suppressor of white apricot N-terminal domain-containing protein Neighboring gene Large ribosomal subunit protein uL14

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003281.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A protein conjugation system essential for autophagy. Mizushima N, et al. Nature, 1998 Sep 24. PMID 9759731
    2. Autophagy regulates ageing in C. elegans. Hars ES, et al. Autophagy, 2007 Mar-Apr. PMID 17204841
    3. HLH-30/TFEB-mediated autophagy functions in a cell-autonomous manner for epithelium intrinsic cellular defense against bacterial pore-forming toxin in C. elegans. Chen HD, et al. Autophagy, 2017 Feb. PMID 27875098, Free PMC Article
    4. The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway. Zhang H, et al. Autophagy, 2013 Dec. PMID 24185444, Free PMC Article
    5. The scaffold protein EPG-7 links cargo-receptor complexes with the autophagic assembly machinery. Lin L, et al. J Cell Biol, 2013 Apr 1. PMID 23530068, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    contributes_to Atg8-family ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein tag activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in autophagosome assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in autophagy IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in autophagy of mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to toxic substance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in determination of adult lifespan IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in determination of adult lifespan IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycophagy IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in piecemeal microautophagy of the nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within_positive_effect plasma membrane repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in xenophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Atg12-Atg5-Atg16 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in autophagosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in autophagosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagophore assembly site membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in phagophore assembly site membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ubiquitin-like protein atg-12
    NP_498228.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003281.10 Reference assembly

      Range
      5697494..5698013 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_065827.3 → NP_498228.1  Ubiquitin-like protein atg-12 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_498228.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q10931
      Conserved Domains (1) summary
      cl28922
      Location:28 → 118
      Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q10931.1

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