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    swan-1 WD_REPEATS_REGION domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 179876, updated on 9-Dec-2024

    Summary

    Official Symbol
    swan-1
    Official Full Name
    WD_REPEATS_REGION domain-containing protein
    Primary source
    WormBase:WBGene00009977
    Locus tag
    CELE_F53C11.8
    See related
    AllianceGenome:WB:WBGene00009977
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables LIM domain binding activity and small GTPase binding activity. Involved in several processes, including negative regulation of phagocytosis, engulfment; regulation of axon extension; and response to heat. Located in cytoplasm. Is expressed widely. Orthologous to human DCAF7 (DDB1 and CUL4 associated factor 7). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See swan-1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    6
    Sequence:
    Chromosome: V; NC_003283.11 (13804395..13807237, complement)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Fibronectin type-III domain-containing protein Neighboring gene WD_REPEATS_REGION domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables LIM domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of cell migration IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of phagocytosis, engulfment IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of axon extension IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to heat IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to osmotic stress IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    WD_REPEATS_REGION domain-containing protein
    NP_506418.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      13804395..13807237 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074017.8NP_506418.1  WD_REPEATS_REGION domain-containing protein [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q93758
      Conserved Domains (2) summary
      COG2319
      Location:36369
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:68110
      7WD40; WD40 repeat [structural motif]