eri-7 Enhanced RNAI (RNA interference) [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: eri-7
Official Full Name: Enhanced RNAI (RNA interference)
Primary source: WormBase:WBGene00016566
Locus tag: CELE_C41D11.7
See related: AllianceGenome:WB:WBGene00016566
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable RNA binding activity and transcription termination site sequence-specific DNA binding activity. Predicted to be involved in termination of RNA polymerase II transcription. Predicted to be active in nuclear body. Is expressed in amphid neurons; gonad; and hypodermis. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 4; hypertension; and spinocerebellar ataxia with axonal neuropathy 2. Orthologous to human MOV10 (Mov10 RNA helicase) and SETX (senataxin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See eri-7 in Genome Data Viewer

Location:: chromosome: I

Exon count:: 10

Sequence:: Chromosome: I; NC_003279.8 (4451194..4456805, complement)

Chromosome I - NC_003279.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003279.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A Small-RNA-Mediated Feedback Loop Maintains Proper Levels of 22G-RNAs in C. elegans.
Title: A Small-RNA-Mediated Feedback Loop Maintains Proper Levels of 22G-RNAs in C. elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C41D11.1 (e-PCR)
- UniSTS:308743

C41D11.7 (e-PCR)
- UniSTS:319122

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables transcription termination site sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in termination of RNA polymerase II transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nuclear body	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Enhanced RNAI (RNA interference)

NP_491374.2

Product from WormBase gene class eri;
Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003279.8 Reference assembly

Range

4451194..4456805 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058973.8 → NP_491374.2 Enhanced RNAI (RNA interference) [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_491374.2

Status: REVIEWED

UniProtKB/TrEMBL

O01976

Conserved Domains (3) summary

pfam13086
Location:67 → 273

AAA_11; AAA domain

pfam13087
Location:284 → 502

AAA_12; AAA domain

pfam13245
Location:77 → 131

AAA_19; Part of AAA domain