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    K02E7.10 Peptidase C1A papain C-terminal domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 186889, updated on 2-Nov-2024

    Summary

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    Official Symbol
    K02E7.10
    Official Full Name
    Peptidase C1A papain C-terminal domain-containing protein
    Primary source
    WormBase:WBGene00019314
    Locus tag
    CELE_K02E7.10
    See related
    AllianceGenome:WB:WBGene00019314
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable cysteine-type endopeptidase activity. Predicted to be involved in proteolysis involved in protein catabolic process. Predicted to be located in membrane. Predicted to be active in extracellular space and lysosome. Human ortholog(s) of this gene implicated in neuropathy and pycnodysostosis. Orthologous to human CTSH (cathepsin H); CTSK (cathepsin K); and CTSS (cathepsin S). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See K02E7.10 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (1065365..1067007, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Uncharacterized protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables cysteine-type endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteolysis involved in protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in lysosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Peptidase C1A papain C-terminal domain-containing protein
    NP_493904.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      1065365..1067007 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_061503.2 → NP_493904.1  Peptidase C1A papain C-terminal domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_493904.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      O17255
      Conserved Domains (1) summary
      cd02248
      Location:82 → 293
      Peptidase_C1A; Peptidase C1A subfamily (MEROPS database nomenclature); composed of cysteine peptidases (CPs) similar to papain, including the mammalian CPs (cathepsins B, C, F, H, L, K, O, S, V, X and W). Papain is an endopeptidase with specific substrate preferences, ...
    Nucleotide Protein
    Heading Accession and Version

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