RPS16 ribosomal protein S16 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RPS16provided by HGNC
Official Full Name: ribosomal protein S16provided by HGNC
Primary source: HGNC:HGNC:10396
See related: Ensembl:ENSG00000105193 MIM:603675; AllianceGenome:HGNC:10396
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: S16; uS9
Summary: Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S9P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in ovary (RPKM 933.9), lymph node (RPKM 484.0) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 19q13.2

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	19	NC_000019.10 (39433137..39435949, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	19	NC_060943.1 (42237400..42240212, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	19	NC_000019.9 (39923777..39926589, complement)

Chromosome 19 - NC_000019.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MicroRNA let-7 Suppresses Influenza A Virus Infection by Targeting RPS16 and Enhancing Type I Interferon Response.
Title: MicroRNA let-7 Suppresses Influenza A Virus Infection by Targeting RPS16 and Enhancing Type I Interferon Response.
USP1-dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells.
Title: USP1-dependent RPS16 protein stability drives growth and metastasis of human hepatocellular carcinoma cells.
These data confirmed RPS16 and TNFSF10 as two direct targets of miR-7641, while gene expression study showed that a group of genes are also deregulated by miR-7641, including many ribosomal proteins that are frequently co-expressed with RPS16 in breast cancer.
Title: MicroRNA-7641 is a regulator of ribosomal proteins and a promising targeting factor to improve the efficacy of cancer therapy.
Report dysregulated expression of RPS16 in disc degeneration.
Title: Dysregulated COL3A1 and RPL8, RPS16, and RPS23 in Disc Degeneration Revealed by Bioinformatics Methods.
Results obtained support the possibility of the autoregulation of rpS13 pre-mRNA splicing through feedback mechanism.
Title: [Human ribosomal protein S16 inhibites excision of the first intron from its own].
Observational study of gene-disease association. (HuGE Navigator)
Title: Diamond-Blackfan anemia: genotype-phenotype correlations in Italian patients with RPL5 and RPL11 mutations.
Data demonstrated that while ribosomal proteins S16 and S5 is able to bind to the 18S rRNA independently, their simultaneous binding has a noticeable synergetic effect.
Title: Interactions of human ribosomal proteins S16 and S5 with an 18S rRNA fragment containing their binding sites.
RpS16 was shown to specifically bind to the transcript forming a stable complex with the apparent dissociation constant of (1.3 +/- 0.1) x 10(-8) M at 20 degrees C.
Title: [Binding of human ribosomal protein S16 with the 18S rRNA fragment 1203-1236/1521-1698].

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Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	HIV-1 Gag interacts with RPL27AP6 as demonstrated by proximity dependent biotinylation proteomics	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G31561 (e-PCR)
- UniSTS:7206

D8S2279 (e-PCR)
- UniSTS:473907

RP_S16_1 (e-PCR)
- UniSTS:55468

HUM0S11D12 (e-PCR)
- UniSTS:63939

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables RNA binding	HDA more info	PubMed
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables structural constituent of ribosome	HDA more info	PubMed
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in cellular response to leukemia inhibitory factor	IEA Inferred from Electronic Annotation more info
involved_in cytoplasmic translation	IC Inferred by Curator more info	PubMed
involved_in cytoplasmic translation	NAS Non-traceable Author Statement more info	PubMed
involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)	IBA Inferred from Biological aspect of Ancestor more info
involved_in rRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in ribosomal small subunit biogenesis	IDA Inferred from Direct Assay more info	PubMed
involved_in ribosomal small subunit biogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in translation	IC Inferred by Curator more info	PubMed
involved_in translation	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	NAS Non-traceable Author Statement more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in cytosolic ribosome	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	HDA more info	PubMed
part_of cytosolic small ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic small ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic small ribosomal subunit	NAS Non-traceable Author Statement more info	PubMed
located_in extracellular exosome	HDA more info	PubMed
located_in focal adhesion	HDA more info	PubMed
located_in membrane	HDA more info	PubMed
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	TAS Traceable Author Statement more info
part_of small ribosomal subunit	HDA more info	PubMed
part_of small-subunit processome	IDA Inferred from Direct Assay more info	PubMed
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: small ribosomal subunit protein uS9

Names: 40S ribosomal protein S16

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001020.6 → NP_001011.1 small ribosomal subunit protein uS9 isoform 1

See identical proteins and their annotated locations for NP_001011.1

Status: REVIEWED

Source sequence(s)

AA890305, AC011500, AK315498

Consensus CDS

CCDS12535.1

UniProtKB/Swiss-Prot

B2RDD5, P17008, P62249

Related

ENSP00000251453.2, ENST00000251453.8

Conserved Domains (1) summary

PLN00210
Location:6 → 146

PLN00210; 40S ribosomal protein S16; Provisional
NM_001321111.2 → NP_001308040.1 small ribosomal subunit protein uS9 isoform 2

Status: REVIEWED

Source sequence(s)

AA890305, AC011500, BC095429

Consensus CDS

CCDS82349.1

UniProtKB/TrEMBL

M0R210

Related

ENSP00000472231.1, ENST00000601655.5

Conserved Domains (1) summary

PLN00210
Location:6 → 129

PLN00210; 40S ribosomal protein S16; Provisional
NM_001363860.2 → NP_001350789.1 small ribosomal subunit protein uS9 isoform 3

Status: REVIEWED

Source sequence(s)

BG340248, CB151553, CD249175

Consensus CDS

CCDS86768.1

UniProtKB/TrEMBL

Q6IPX4

Related

ENSP00000367806.2, ENST00000339471.8

Conserved Domains (1) summary

cl00334
Location:6 → 86

Ribosomal_S9; Ribosomal protein S9/S16