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    M04D5.1 Thioredoxin domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 13182108, updated on 9-Dec-2024

    Summary

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    Official Symbol
    M04D5.1
    Official Full Name
    Thioredoxin domain-containing protein
    Primary source
    WormBase:WBGene00014807
    Locus tag
    CELE_M04D5.1
    See related
    AllianceGenome:WB:WBGene00014807
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable protein disulfide isomerase activity. Predicted to be involved in protein folding and response to endoplasmic reticulum stress. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta); PDIA2 (protein disulfide isomerase family A member 2); and PDILT (protein disulfide isomerase like, testis expressed). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See M04D5.1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    4
    Sequence:
    Chromosome: I; NC_003279.8 (11334056..11338112)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene Phosphotransferase Neighboring gene putative cyclin-dependent kinase 9 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Bm5235

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in response to endoplasmic reticulum stress IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Thioredoxin domain-containing protein
    NP_001251622.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      11334056..11338112
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001264693.2 → NP_001251622.1  Thioredoxin domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_001251622.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      H2FLL2
      Conserved Domains (2) summary
      TIGR01130
      Location:2 → 329
      ER_PDI_fam; protein disulfide isomerase, eukaryotic
      cl00388
      Location:229 → 311
      Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    Nucleotide Protein
    Heading Accession and Version

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