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    ERD2 Erd2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852240, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERD2
    Official Full Name
    Erd2p
    Primary source
    SGD:S000000136
    Locus tag
    YBL040C
    See related
    AllianceGenome:SGD:S000000136; FungiDB:YBL040C; VEuPathDB:YBL040C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables HDEL sequence binding activity. Involved in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Located in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 21. Orthologous to several human genes including KDELR2 (KDEL endoplasmic reticulum protein retention receptor 2) and KDELR3 (KDEL endoplasmic reticulum protein retention receptor 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ERD2 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    2
    Sequence:
    Chromosome: II; NC_001134.8 (142112..142868, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uridine permease Neighboring gene proteasome core particle subunit beta 6 Neighboring gene Min6p Neighboring gene CTP synthase URA7

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Changing the specificity of the sorting receptor for luminal endoplasmic reticulum proteins. Semenza JC, et al. J Mol Biol, 1992 Mar 5. PMID 1312604
    2. Receptor for retrograde transport in the apicomplexan parasite Toxoplasma gondii. Pfluger SL, et al. Eukaryot Cell, 2005 Feb. PMID 15701805, Free PMC Article
    3. Retrieval of HDEL proteins is required for growth of yeast cells. Townsley FM, et al. J Cell Biol, 1994 Oct. PMID 7929564, Free PMC Article
    4. The ERD2 gene determines the specificity of the luminal ER protein retention system. Lewis MJ, et al. Cell, 1990 Jun 29. PMID 2194671
    5. ERD2, a yeast gene required for the receptor-mediated retrieval of luminal ER proteins from the secretory pathway. Semenza JC, et al. Cell, 1990 Jun 29. PMID 2194670

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ER retention sequence binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ER retention sequence binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables HDEL sequence binding IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein retention in ER lumen IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein retention in ER lumen IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cis-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Erd2p
    NP_009513.1
    • HDEL receptor; an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      142112..142868 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178280.1 → NP_009513.1  TPA: Erd2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009513.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPV8, P18414
      UniProtKB/TrEMBL
      A6ZKQ6, B3LNH9, C7GNC2, C8Z3Q7, N1P8S1
      Conserved Domains (1) summary
      COG5196
      Location:1 → 219
      ERD2; ER lumen protein retaining receptor [Intracellular trafficking and secretion]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P18414.1

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