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    PRS4 ribose phosphate diphosphokinase subunit PRS4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852211, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PRS4
    Official Full Name
    ribose phosphate diphosphokinase subunit PRS4
    Primary source
    SGD:S000000164
    Locus tag
    YBL068W
    See related
    AllianceGenome:SGD:S000000164; FungiDB:YBL068W; VEuPathDB:YBL068W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to ribose phosphate diphosphokinase activity. Involved in 5-phosphoribose 1-diphosphate biosynthetic process. Located in cytoplasm. Part of ribose phosphate diphosphokinase complex. Used to study diabetes insipidus and fundus dystrophy. Human ortholog(s) of this gene implicated in Arts syndrome; X-linked deafness 1; X-linked recessive disease (multiple); gout; and retinitis pigmentosa. Orthologous to human PRPS1 (phosphoribosyl pyrophosphate synthetase 1); PRPS1L1 (phosphoribosyl pyrophosphate synthetase 1 like 1); and PRPS2 (phosphoribosyl pyrophosphate synthetase 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PRS4 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (92414..93394)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Kti11p Neighboring gene Ast1p Neighboring gene ubiquitin-specific protease UBP13 Neighboring gene Sef1p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Prenatal growth restriction, retinal dystrophy, diabetes insipidus and white matter disease: expanding the spectrum of PRPS1-related disorders. Al-Maawali A, et al. Eur J Hum Genet, 2015 Mar. PMID 24961627, Free PMC Article
    2. Impaired proteasome function rescues thermosensitivity of yeast cells lacking the coatomer subunit epsilon-COP. Kimata Y, et al. J Biol Chem, 2000 Apr 7. PMID 10744762
    3. Phosphoribosylpyrophosphate synthetase (PRS): a new gene family in Saccharomyces cerevisiae. Carter AT, et al. Yeast, 1994 Aug. PMID 7992503
    4. PRS1 is a key member of the gene family encoding phosphoribosylpyrophosphate synthetase in Saccharomyces cerevisiae. Carter AT, et al. Mol Gen Genet, 1997 Mar 26. PMID 9108276
    5. PRS5, the fifth member of the phosphoribosyl pyrophosphate synthetase gene family in Saccharomyces cerevisiae, is essential for cell viability in the absence of either PRS1 or PRS3. Hernando Y, et al. J Bacteriol, 1998 Dec. PMID 9829955, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ribose phosphate diphosphokinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ribose phosphate diphosphokinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in 5-phosphoribose 1-diphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribonucleoside monophosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of ribose phosphate diphosphokinase complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribose phosphate diphosphokinase complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ribose phosphate diphosphokinase subunit PRS4
    NP_009485.3
    • 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP; which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication; a missense mutation in the conserved residue R196 of its human homolog PRPS1 is pathogenic

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      92414..93394
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178308.2 → NP_009485.3  TPA: ribose phosphate diphosphokinase subunit PRS4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009485.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPT3, P38063, Q9HGQ6
      UniProtKB/TrEMBL
      A6ZKN2, B3LNK2, C7GN99, G2W8U2, N1P9M4
      Conserved Domains (1) summary
      COG0462
      Location:11 → 322
      PrsA; Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism, Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38063.3

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