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    NTC20 Ntc20p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852486, updated on 9-Dec-2024

    Summary

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    Official Symbol
    NTC20
    Official Full Name
    Ntc20p
    Primary source
    SGD:S000000392
    Locus tag
    YBR188C
    See related
    AllianceGenome:SGD:S000000392; FungiDB:YBR188C; VEuPathDB:YBR188C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to contribute to first spliceosomal transesterification activity. Involved in mRNA splicing, via spliceosome. Part of Prp19 complex and U2-type catalytic step 1 spliceosome. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See NTC20 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (603685..604107, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Pch2p Neighboring gene putative ribosome biosynthesis protein GDT1 Neighboring gene ribosomal 40S subunit protein S9B Neighboring gene ribosomal 60S subunit protein L21A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Snt309p modulates interactions of Prp19p with its associated components to stabilize the Prp19p-associated complex essential for pre-mRNA splicing. Chen HR, et al. Proc Natl Acad Sci U S A, 1999 May 11. PMID 10318896, Free PMC Article
    2. The Isy1p component of the NineTeen complex interacts with the ATPase Prp16p to regulate the fidelity of pre-mRNA splicing. Villa T, et al. Genes Dev, 2005 Aug 15. PMID 16103217, Free PMC Article
    3. DEAH-box ATPase Prp16 has dual roles in remodeling of the spliceosome in catalytic steps. Tseng CK, et al. RNA, 2011 Jan. PMID 21098140, Free PMC Article
    4. Mutations in genes of Saccharomyces cerevisiae encoding pre-mRNA splicing factors cause cell cycle arrest through activation of the spindle checkpoint. Dahan O, et al. Nucleic Acids Res, 2002 Oct 15. PMID 12384582, Free PMC Article
    5. Cef1p is a component of the Prp19p-associated complex and essential for pre-mRNA splicing. Tsai WY, et al. J Biol Chem, 1999 Apr 2. PMID 10092627

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to first spliceosomal transesterification activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Prp19 complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type catalytic step 1 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Ntc20p
    NP_009747.3
    • Member of the NineTeen Complex (NTC); this complex contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      603685..604107 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178536.3 → NP_009747.3  TPA: Ntc20p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009747.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQI3, P38302
      UniProtKB/TrEMBL
      A6ZLC9, G2W9J0, N1P9J8
      Conserved Domains (1) summary
      pfam08315
      Location:3 → 127
      cwf18; cwf18 pre-mRNA splicing factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38302.1

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