NTH1 alpha,alpha-trehalase NTH1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: NTH1
Official Full Name: alpha,alpha-trehalase NTH1
Primary source: SGD:S000002408
Locus tag: YDR001C
See related: AllianceGenome:SGD:S000002408; FungiDB:YDR001C; VEuPathDB:YDR001C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable alpha,alpha-trehalase activity. Involved in cellular response to desiccation and trehalose catabolic process. Located in cytoplasm. Orthologous to human TREH (trehalase). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See NTH1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 1

Sequence:: Chromosome: IV; NC_001136.10 (450220..452475, complement)

Chromosome IV - NC_001136.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001136.10

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

EF-hand like motif-containing domain functions as the intermediary through which the 14-3-3 protein modulates the function of the catalytic domain of Nth1
Title: Role of the EF-hand-like motif in the 14-3-3 protein-mediated activation of yeast neutral trehalase Nth1.
14-3-3 proteins are required for both activation of trehalase and phosphorylation of the ser21 and ser83 sites.
Title: In vivo phosphorylation of Ser21 and Ser83 during nutrient-induced activation of the yeast protein kinase A (PKA) target trehalase.
The behaviour of trehalase mutant strains demonstrates the participation of trehalases Nth1p, Nth2p and Ath1p in the mobilization of intracellular trehalose during growth recovery after saline stress.
Title: The three trehalases Nth1p, Nth2p and Ath1p participate in the mobilization of intracellular trehalose required for recovery from saline stress in Saccharomyces cerevisiae.
Gene disruption of NTH1 and ATH1 increased tolerance to freezing, heat, high-sugar and ethanol concentration.
Title: [Construction and stress tolerance of trehalase mutant in Saccharomyces cerevisiae].

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables alpha,alpha-trehalase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alpha,alpha-trehalase activity	IEA Inferred from Electronic Annotation more info
enables alpha,alpha-trehalase activity	TAS Traceable Author Statement more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables trehalase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to desiccation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in trehalose catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in trehalose catabolic process	IEA Inferred from Electronic Annotation more info
involved_in trehalose catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: alpha,alpha-trehalase NTH1

NP_010284.1

EC 3.2.1.28

Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; phosphorylated and activated by Cdc28p at the G1/S phase transition to coordinately regulate carbohydrate metabolism and the cell cycle; inhibited by Dcs1p; NTH1 has a paralog, NTH2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001136.10 Reference assembly

Range

450220..452475 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001180309.1 → NP_010284.1 TPA: alpha,alpha-trehalase NTH1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_010284.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VRY8, E9P9U7, P32356

UniProtKB/TrEMBL

A6ZXW6, B3LGQ8, B5VFR1, C7GXZ0, N1P7X5

Conserved Domains (1) summary

COG1626
Location:88 → 726

TreA; Neutral trehalase [Carbohydrate transport and metabolism]