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    POL5 DNA-directed DNA polymerase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856655, updated on 9-Dec-2024

    Summary

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    Official Symbol
    POL5
    Official Full Name
    DNA-directed DNA polymerase
    Primary source
    SGD:S000000781
    Locus tag
    YEL055C
    See related
    AllianceGenome:SGD:S000000781; FungiDB:YEL055C; VEuPathDB:YEL055C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables rDNA binding activity and rRNA primary transcript binding activity. Involved in positive regulation of ribosome biogenesis; rRNA metabolic process; and ribosomal large subunit assembly. Located in nucleolus. Orthologous to human MYBBP1A (MYB binding protein 1a). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See POL5 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (48471..51539, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene Sdd1p Neighboring gene Hat2p Neighboring gene ncRNA Neighboring gene ribosomal 60S subunit protein L12A

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Yeast POL5 is an evolutionarily conserved regulator of rDNA transcription unrelated to any known DNA polymerases. Yang W, et al. Cell Cycle, 2003 Mar-Apr. PMID 12695662
    2. The fifth essential DNA polymerase phi in Saccharomyces cerevisiae is localized to the nucleolus and plays an important role in synthesis of rRNA. Shimizu K, et al. Proc Natl Acad Sci U S A, 2002 Jul 9. PMID 12093911, Free PMC Article
    3. Pol5 is an essential ribosome biogenesis factor required for 60S ribosomal subunit maturation in Saccharomyces cerevisiae. Ramos-Sáenz A, et al. RNA, 2019 Nov. PMID 31413149, Free PMC Article
    4. Pol5 is required for recycling of small subunit biogenesis factors and for formation of the peptide exit tunnel of the large ribosomal subunit. Braun CM, et al. Nucleic Acids Res, 2020 Jan 10. PMID 31745560, Free PMC Article
    5. Proteins and RNA sequences required for the transition of the t-Utp complex into the SSU processome. Gallagher JEG. FEMS Yeast Res, 2019 Jan 1. PMID 30445532, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pol5 is required for recycling of small subunit biogenesis factors and for formation of the peptide exit tunnel of the large ribosomal subunit.
      Title: Pol5 is required for recycling of small subunit biogenesis factors and for formation of the peptide exit tunnel of the large ribosomal subunit.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables rDNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables rDNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables rRNA primary transcript binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of ribosome biogenesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of ribosome biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in rRNA processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in rRNA transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleolus HDA PubMed 
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed DNA polymerase
    NP_010859.1
    • Protein involved in 60S assembly and pre-40S AFs recycling; has sequence similarity to human MybBP1A and weak sequence similarity to B-type DNA polymerases; not required for chromosomal DNA replication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      48471..51539 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178870.1 → NP_010859.1  TPA: DNA-directed DNA polymerase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010859.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLJ5, P39985, Q9Y737
      UniProtKB/TrEMBL
      C7GXE2, N1P5B5
      Conserved Domains (1) summary
      pfam04931
      Location:46 → 859
      DNA_pol_phi; DNA polymerase phi
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P39985.1

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