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    PRO3 pyrroline-5-carboxylate reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856744, updated on 17-Dec-2024

    Summary

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    Official Symbol
    PRO3
    Official Full Name
    pyrroline-5-carboxylate reductase
    Primary source
    SGD:S000000825
    Locus tag
    YER023W
    See related
    AllianceGenome:SGD:S000000825; FungiDB:YER023W; VEuPathDB:YER023W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ORE2
    Summary
    Enables pyrroline-5-carboxylate reductase activity. Involved in proline biosynthetic process. Located in cytoplasm. Human ortholog(s) of this gene implicated in autosomal recessive cutis laxa type IIB; autosomal recessive cutis laxa type IIIB; and hypomyelinating leukodystrophy 10. Orthologous to human PYCR1 (pyrroline-5-carboxylate reductase 1); PYCR2 (pyrroline-5-carboxylate reductase 2); and PYCR3 (pyrroline-5-carboxylate reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PRO3 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (201076..201936)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene proteasome regulatory particle lid subunit RPN3 Neighboring gene Srb4p Neighboring gene carnitine O-acetyltransferase YAT2 Neighboring gene translation initiation factor eIF2 subunit gamma

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and sequence analysis of the cDNA encoding delta 1-pyrroline-5-carboxylate reductase from Zalerion arboricola. Kelly R, et al. Gene, 1996 Jun 12. PMID 8654976
    2. Proline biosynthesis in Saccharomyces cerevisiae: analysis of the PRO3 gene, which encodes delta 1-pyrroline-5-carboxylate reductase. Brandriss MC, et al. J Bacteriol, 1992 Jun. PMID 1592829, Free PMC Article
    3. Subcellular compartmentation in control of converging pathways for proline and arginine metabolism in Saccharomyces cerevisiae. Brandriss MC, et al. J Bacteriol, 1981 Mar. PMID 7009582, Free PMC Article
    4. ore2, a mutation affecting proline biosynthesis in the yeast Saccharomyces cerevisiae, leads to a cdc phenotype. Neuville P, et al. Mol Gen Genet, 1992 Aug. PMID 1508147
    5. The Cdc25/Ras/cAMP-dependent protein kinase A signaling pathway regulates proline utilization in wine yeast Saccharomyces cerevisiae under a wine fermentation model. Nishimura A, et al. Biosci Biotechnol Biochem, 2022 Aug 24. PMID 35749464

    See all (58) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pyrroline-5-carboxylate reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in L-proline biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in L-proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proline biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    pyrroline-5-carboxylate reductase
    NP_010940.3
    • Cytosolic delta 1-pyrroline-5-carboxylate reductase; catalyzes the last step in proline biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      201076..201936
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178914.3 → NP_010940.3  TPA: pyrroline-5-carboxylate reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010940.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLS2, P32263
      UniProtKB/TrEMBL
      A6ZQX2, B3LS36, C7GTD5, C8Z724, G2WCQ6, N1P5I0
      Conserved Domains (1) summary
      COG0345
      Location:2 → 284
      ProC; Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32263.1

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