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    CLG1 Clg1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852657, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CLG1
    Official Full Name
    Clg1p
    Primary source
    SGD:S000003183
    Locus tag
    YGL215W
    See related
    AllianceGenome:SGD:S000003183; FungiDB:YGL215W; VEuPathDB:YGL215W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in positive regulation of macroautophagy. Part of cyclin-dependent protein kinase holoenzyme complex. Orthologous to human CNPPD1 (cyclin Pas1/PHO80 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CLG1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (87981..89339)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene ERMES complex subunit MDM34 Neighboring gene tubulin-dependent ATPase KIP3 Neighboring gene SKI complex subunit WD repeat protein SKI8 Neighboring gene Vam7p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CLG1, a new cyclin-like gene of Saccharomyces cerevisiae. Matsumoto Y, et al. Yeast, 1993 Aug. PMID 8212900
    2. Activity of a ubiquitin ligase adaptor is regulated by disordered insertions in its arrestin domain. Baile MG, et al. Mol Biol Cell, 2019 Dec 1. PMID 31618110, Free PMC Article
    3. Cyclin-dependent kinase Pho85p and its cyclins are involved in replicative lifespan through multiple pathways in yeast. Nakajima T, et al. FEBS Lett, 2020 Apr. PMID 31797348
    4. Positive or negative roles of different cyclin-dependent kinase Pho85-cyclin complexes orchestrate induction of autophagy in Saccharomyces cerevisiae. Yang Z, et al. Mol Cell, 2010 Apr 23. PMID 20417603, Free PMC Article
    5. A family of cyclin-like proteins that interact with the Pho85 cyclin-dependent kinase. Measday V, et al. Mol Cell Biol, 1997 Mar. PMID 9032248, Free PMC Article

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase regulator activity ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables protein kinase binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in positive regulation of macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of cyclin-dependent protein kinase holoenzyme complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of cyclin-dependent protein kinase holoenzyme complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Clg1p
    NP_011300.1
    • Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      87981..89339
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181080.1 → NP_011300.1  TPA: Clg1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011300.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VTU1, P35190
      UniProtKB/TrEMBL
      A6ZTX5, C7GWY3
      Conserved Domains (1) summary
      cd20557
      Location:168 → 260
      CYCLIN_ScPCL1-like; cyclin box found in Saccharomyces cerevisiae G1/S-specific cyclin PCL1, PCL2 and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35190.1

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