U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    PEX8 Pex8p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852968, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    PEX8
    Official Full Name
    Pex8p
    Primary source
    SGD:S000003309
    Locus tag
    YGR077C
    See related
    AllianceGenome:SGD:S000003309; FungiDB:YGR077C; VEuPathDB:YGR077C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PAS6
    Summary
    Enables protein-macromolecule adaptor activity. Involved in protein import into peroxisome matrix. Part of peroxisomal importomer complex. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See PEX8 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (637744..639513, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mRNA splicing protein SMD1 Neighboring gene U4/U6-U5 snRNP complex subunit PRP38 Neighboring gene mitochondrial 54S ribosomal protein YmL25 Neighboring gene tubulin-binding prefolding complex subunit PAC10 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Multiple targeting modules on peroxisomal proteins are not redundant: discrete functions of targeting signals within Pmp47 and Pex8p. Wang X, et al. Mol Biol Cell, 2004 Apr. PMID 14742703, Free PMC Article
    2. Pex8p, an intraperoxisomal peroxin of Saccharomyces cerevisiae required for protein transport into peroxisomes binds the PTS1 receptor pex5p. Rehling P, et al. J Biol Chem, 2000 Feb 4. PMID 10652355
    3. The peroxisomal importomer constitutes a large and highly dynamic pore. Meinecke M, et al. Nat Cell Biol, 2010 Mar. PMID 20154681
    4. Saccharomyces cerevisiae PTS1 receptor Pex5p interacts with the SH3 domain of the peroxisomal membrane protein Pex13p in an unconventional, non-PXXP-related manner. Bottger G, et al. Mol Biol Cell, 2000 Nov. PMID 11071920, Free PMC Article
    5. Isolation of peroxisome assembly mutants from Saccharomyces cerevisiae with different morphologies using a novel positive selection procedure. Van der Leij I, et al. J Cell Biol, 1992 Oct. PMID 1356111, Free PMC Article

    See all (53) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables protein-macromolecule adaptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in peroxisome organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of peroxisomal importomer complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    Pex8p
    NP_011591.1
    • Intraperoxisomal organizer of the peroxisomal import machinery; organizes the formation of the importomer complex, bridging the docking complex with the RING finger complex; tightly associated with the lumenal face of the peroxisomal membrane; essential for peroxisome biogenesis; binds PTS1-signal receptor Pex5p, and PTS2-signal receptor Pex7p

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      637744..639513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181206.1 → NP_011591.1  TPA: Pex8p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011591.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VUK9, P53248
      UniProtKB/TrEMBL
      A6ZV59, B3LIE9, B5VJ18, C8Z8X1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53248.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools