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    PET54 Pet54p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853137, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PET54
    Official Full Name
    Pet54p
    Primary source
    SGD:S000003454
    Locus tag
    YGR222W
    See related
    AllianceGenome:SGD:S000003454; FungiDB:YGR222W; VEuPathDB:YGR222W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA 5'-UTR binding activity; pre-mRNA intronic binding activity; and translation regulator activity. Involved in Group I intron splicing; mitochondrial mRNA processing; and positive regulation of mitochondrial translation. Located in mitochondrial inner membrane and mitochondrial matrix. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PET54 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (939923..940804)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene Tos2p Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Hsv2p Neighboring gene azole transporter

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of mRNAs and coding potential of the PET54 gene from Saccharomyces cerevisiae. Burke KA, et al. Biochem Int, 1991 Sep. PMID 1724152
    2. Genetic evidence that different functional domains of the PET54 gene product facilitate expression of the mitochondrial genes COX1 and COX3 in Saccharomyces cerevisiae. Valencik ML, et al. Mol Cell Biol, 1991 May. PMID 1850094, Free PMC Article
    3. The PET54 gene of Saccharomyces cerevisiae: characterization of a nuclear gene encoding a mitochondrial translational activator and subcellular localization of its product. Costanzo MC, et al. Genetics, 1989 Jun. PMID 2548921, Free PMC Article
    4. A point mutation in the 5'-untranslated leader that affects translational activation of the mitochondrial COX3 mRNA. Costanzo MC, et al. Curr Genet, 1995 Jun. PMID 8536314
    5. Mitochondrial protein synthesis is not required for efficient excision of intron aI5 beta from COX1 pre-mRNA in Saccharomyces cerevisiae. Johnson CH, et al. Mol Gen Genet, 1997 Sep. PMID 9341683

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Pet54 physically interacts with the COX1 mRNA, and this binding was independent of the presence of Mss51.
      Title: A Novel Function of Pet54 in Regulation of Cox1 Synthesis in Saccharomyces cerevisiae Mitochondria.
    2. Competition experiments show that the COX3 5'UTL and aI5beta intron RNAs bind to the same or overlapping surface on Pet54p.
      Title: A shared RNA-binding site in the Pet54 protein is required for translational activation and group I intron splicing in yeast mitochondria.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 5'-UTR binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables pre-mRNA intronic binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables translation regulator activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Group I intron splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Group I intron splicing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial mRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of mitochondrial translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrial matrix IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Pet54p
    NP_011738.3
    • Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing; also stimulates efficient synthesis of Cox1p

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      939923..940804
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181351.3 → NP_011738.3  TPA: Pet54p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011738.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV04, P10834
      UniProtKB/TrEMBL
      A6ZUN2, B3LI16, B5VJG1, C8Z9B4, G2WEV0, N1P9Y6
      Conserved Domains (1) summary
      smart00361
      Location:211 → 270
      RRM_1; RNA recognition motif
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10834.1

    Gene LinkOut

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