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    SDA1 Sda1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853160, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SDA1
    Official Full Name
    Sda1p
    Primary source
    SGD:S000003477
    Locus tag
    YGR245C
    See related
    AllianceGenome:SGD:S000003477; FungiDB:YGR245C; VEuPathDB:YGR245C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in ribosomal large subunit biogenesis; ribosomal large subunit export from nucleus; and traversing start control point of mitotic cell cycle. Located in nucleus. Orthologous to human SDAD1 (SDA1 domain containing 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SDA1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (979765..982068, complement)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene mitochondrial pyruvate carrier Neighboring gene succinate--CoA ligase (GDP-forming) subunit beta Neighboring gene transcription factor TFIIIB subunit BRF1 Neighboring gene 2',3'-cyclic-nucleotide 3'-phosphodiesterase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Saccharomyces cerevisiae SDA1 gene is required for actin cytoskeleton organization and cell cycle progression. Buscemi G, et al. J Cell Sci, 2000 Apr. PMID 10704371
    2. Expression and localization studies of hSDA, the human ortholog of the yeast SDA1 gene. Babbio F, et al. Cell Cycle, 2004 Apr. PMID 14976432
    3. The Sda1 protein is required for passage through start. Zimmerman ZA, et al. Mol Biol Cell, 2001 Jan. PMID 11160833, Free PMC Article
    4. The yeast kinase Swe1 is required for proper entry into cell cycle after arrest due to ribosome biogenesis and protein synthesis defects. Saracino F, et al. Cell Cycle, 2004 May. PMID 15107621
    5. A pre-ribosome with a tadpole-like structure functions in ATP-dependent maturation of 60S subunits. Nissan TA, et al. Mol Cell, 2004 Jul 23. PMID 15260980

    See all (76) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit biogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosomal large subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ribosome biogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in traversing start control point of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Sda1p
    NP_011761.3
    • Protein required for actin organization and passage through Start; highly conserved nuclear protein; required for actin cytoskeleton organization; plays a critical role in G1 events; binds Nap1p; involved in 60S ribosome biogenesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      979765..982068 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181374.3 → NP_011761.3  TPA: Sda1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011761.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VV25, P53313
      UniProtKB/TrEMBL
      A6ZUQ3, B3LHZ5, C7GNI4, C8Z9D7, G2WEX1, N1P2M8
      Conserved Domains (2) summary
      pfam05285
      Location:459 → 765
      SDA1
      pfam08158
      Location:93 → 142
      NUC130_3NT; NUC130/3NT domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53313.1

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