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    CUP1-2 metallothionein CUP1-2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856452, updated on 17-Dec-2024

    Summary

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    Official Symbol
    CUP1-2
    Official Full Name
    metallothionein CUP1-2
    Primary source
    SGD:S000001097
    Locus tag
    YHR055C
    See related
    AllianceGenome:SGD:S000001097; FungiDB:YHR055C; VEuPathDB:YHR055C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CUP1
    Summary
    Enables cadmium ion binding activity; copper ion binding activity; and superoxide dismutase activity. Involved in detoxification of cadmium ion; detoxification of copper ion; and removal of superoxide radicals. Located in cytosol. Is active in mitochondrial intermembrane space. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See CUP1-2 in Genome Data Viewer
    Location:
    chromosome: VIII
    Exon count:
    1
    Sequence:
    Chromosome: VIII; NC_001140.6 (214533..214718, complement)

    Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene metallothionein CUP1-1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene Rsc30p Neighboring gene peptidylprolyl isomerase CPR2

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001140.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Incorporation of copper into the yeast Saccharomyces cerevisiae. Identification of Cu(I)--metallothionein in intact yeast cells. Presta A, et al. J Inorg Biochem, 1997 Jun. PMID 9161010
    2. Heat shock transcription factor activates yeast metallothionein gene expression in response to heat and glucose starvation via distinct signalling pathways. Tamai KT, et al. Mol Cell Biol, 1994 Dec. PMID 7969152, Free PMC Article
    3. Mössbauer studies on iron(II)-substituted yeast metallothionein. Ding XQ, et al. Eur J Biochem, 1994 Aug 1. PMID 8055961
    4. Dominance of metallothionein in metal ion buffering in yeast capable of synthesis of (gamma EC)nG isopeptides. Yu W, et al. J Biol Chem, 1994 Aug 19. PMID 8063718
    5. Versatile cassettes designed for the copper inducible expression of proteins in yeast. Macreadie IG, et al. Plasmid, 1989 Mar. PMID 2500675

    See all (107) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables antioxidant activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables antioxidant activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables cadmium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables cadmium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables copper ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables copper ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables superoxide dismutase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in detoxification of cadmium ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detoxification of cadmium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detoxification of copper ion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in detoxification of copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in removal of superoxide radicals IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in removal of superoxide radicals IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in response to copper ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytosol HDA PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in mitochondrial intermembrane space IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    metallothionein CUP1-2
    NP_011920.1
    • Metallothionein; binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C; CUP1-2 has a paralog, CUP1-1, that arose from a segmental duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001140.6 Reference assembly

      Range
      214533..214718 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179183.1 → NP_011920.1  TPA: metallothionein CUP1-2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011920.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DL02, P07215, P0CX80, P0CX81
      UniProtKB/TrEMBL
      A0A0A1HAP2, A6ZSW1, B3LSH4, C7GV24, C8Z9J0, G2WFC7
      Conserved Domains (1) summary
      pfam11403
      Location:9 → 47
      Yeast_MT; Yeast metallothionein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P0CX80.1
    P0CX81.1

    Gene LinkOut

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    Other Literature Sources
    Molecular Biology Databases
    Research Materials