NOT3 CCR4-NOT core subunit NOT3 [Saccharomyces cerevisiae S288C] - Gene

Summary

Official Symbol: NOT3
Official Full Name: CCR4-NOT core subunit NOT3
Primary source: SGD:S000001300
Locus tag: YIL038C
See related: AllianceGenome:SGD:S000001300; FungiDB:YIL038C; VEuPathDB:YIL038C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Involved in positive regulation of RNA metabolic process and protein ubiquitination. Located in cytoplasm. Part of CCR4-NOT core complex. Orthologous to human CNOT3 (CCR4-NOT transcription complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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Chromosome IX - NC_001141.2 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in deadenylation-dependent decapping of nuclear-transcribed mRNA	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IBA Inferred from Biological aspect of Ancestor more info
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IDA Inferred from Direct Assay more info	PubMed
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription elongation by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in protein ubiquitination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of CCR4-NOT core complex	IBA Inferred from Biological aspect of Ancestor more info
part_of CCR4-NOT core complex	IEA Inferred from Electronic Annotation more info
part_of CCR4-NOT core complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

NP_012226.3

Component of the CCR4-NOT core complex, involved in mRNA decapping; involved in transcription initiation and elongation and in mRNA degradation; conserved lysine in human homolog of Not3p and Not5p is mutated in cancers

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The following sections contain reference sequences that belong to a specific genome build. Explain