PEP8 retromer subunit PEP8 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PEP8
Official Full Name: retromer subunit PEP8
Primary source: SGD:S000003589
Locus tag: YJL053W
See related: AllianceGenome:SGD:S000003589; FungiDB:YJL053W; VEuPathDB:YJL053W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: GRD6; VPS26; VPT4
Summary: Enables protein transporter activity. Involved in protein retention in Golgi apparatus and retrograde transport, endosome to Golgi. Located in endosome. Part of retromer, cargo-selective complex. Human ortholog(s) of this gene implicated in diabetic retinopathy and type 2 diabetes mellitus. Orthologous to human VPS26A (VPS26 retromer complex component A) and VPS26B (VPS26 retromer complex component B). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PEP8 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (335898..337037)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mih1 directly modulates the phosphorylation state of the Vps26 retromer subunit; mutations engineered to mimic these states modulate the binding affinities of Vps26 for a retromer cargo, resulting in corresponding changes in cargo sorting at the endosome.
Title: A CDC25 family protein phosphatase gates cargo recognition by the Vps26 retromer subunit.
the R(98) residue, which is part of a conserved PRLYL motif, is critical for Vps35p binding to Vps26p, while both R(98) and residues 733-944 are needed for efficient binding to Vps29p
Title: Structural features of vps35p involved in interaction with other subunits of the retromer complex.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables protein transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein transporter activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in intracellular protein transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular protein transport	IEA Inferred from Electronic Annotation more info
involved_in protein retention in Golgi apparatus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein transport	IEA Inferred from Electronic Annotation more info
involved_in retrograde transport, endosome to Golgi	IBA Inferred from Biological aspect of Ancestor more info
involved_in retrograde transport, endosome to Golgi	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome	IDA Inferred from Direct Assay more info	PubMed
located_in fungal-type vacuole membrane	HDA more info	PubMed
part_of retromer complex	IBA Inferred from Biological aspect of Ancestor more info
part_of retromer complex	IMP Inferred from Mutant Phenotype more info	PubMed
part_of retromer complex	IPI Inferred from Physical Interaction more info	PubMed
part_of retromer, cargo-selective complex	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: retromer subunit PEP8

NP_012482.1

Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

335898..337037

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181486.1 → NP_012482.1 TPA: retromer subunit PEP8 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012482.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWC9, E9P910, P40335

UniProtKB/TrEMBL

A6ZPS1, B5VLC3, G2WGW3, N1P0V9

Conserved Domains (1) summary

pfam03643
Location:5 → 364

Vps26; Vacuolar protein sorting-associated protein 26