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    TIM54 Tim54p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853392, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TIM54
    Official Full Name
    Tim54p
    Primary source
    SGD:S000003590
    Locus tag
    YJL054W
    See related
    AllianceGenome:SGD:S000003590; FungiDB:YJL054W; VEuPathDB:YJL054W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to protein transmembrane transporter activity. Involved in protein insertion into mitochondrial inner membrane. Located in mitochondrion. Part of TIM22 mitochondrial import inner membrane insertion complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TIM54 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (334265..335701)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Zap1p Neighboring gene Log1p Neighboring gene retromer subunit PEP8 Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Tim54p-Tim22p complex mediates insertion of proteins into the mitochondrial inner membrane. Kerscher O, et al. J Cell Biol, 1997 Dec 29. PMID 9412462, Free PMC Article
    2. Phosphatidylcholine Affects Inner Membrane Protein Translocases of Mitochondria. Schuler MH, et al. J Biol Chem, 2016 Sep 2. PMID 27402832, Free PMC Article
    3. The assembly pathway of the mitochondrial carrier translocase involves four preprotein translocases. Wagner K, et al. Mol Cell Biol, 2008 Jul. PMID 18458057, Free PMC Article
    4. Tim9p, an essential partner subunit of Tim10p for the import of mitochondrial carrier proteins. Koehler CM, et al. EMBO J, 1998 Nov 16. PMID 9822593, Free PMC Article
    5. Transport of the ADP/ATP carrier of mitochondria from the TOM complex to the TIM22.54 complex. Endres M, et al. EMBO J, 1999 Jun 15. PMID 10369662, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Tim54p links protein import, assembly, and turnover pathways in the mitochondrion.
      Title: Tim54p connects inner membrane assembly and proteolytic pathways in the mitochondrion.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    NOT enables lipid kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to protein transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein insertion into mitochondrial inner membrane IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in protein insertion into mitochondrial inner membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in sphingosine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Tim54p
    NP_012481.3
    • Component of the mitochondrial TIM22 complex; involved in insertion of polytopic proteins into the inner membrane

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      334265..335701
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181487.3 → NP_012481.3  TPA: Tim54p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012481.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWC8, P47045
      UniProtKB/TrEMBL
      B3LQ56, G2WGW2, N1P358
      Conserved Domains (1) summary
      pfam11711
      Location:20 → 466
      Tim54; Inner membrane protein import complex subunit Tim54
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P47045.1

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