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    URA6 bifunctional uridylate/adenylate kinase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853844, updated on 9-Dec-2024

    Summary

    Official Symbol
    URA6
    Official Full Name
    bifunctional uridylate/adenylate kinase
    Primary source
    SGD:S000001507
    Locus tag
    YKL024C
    See related
    AllianceGenome:SGD:S000001507; FungiDB:YKL024C; VEuPathDB:YKL024C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    SOC8
    Summary
    Enables UMP/dUMP kinase activity and adenylate kinase activity. Involved in 'de novo' pyrimidine nucleobase biosynthetic process. Located in cytoplasm and nucleus. Used to study cancer. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma. Orthologous to human CMPK1 (cytidine/uridine monophosphate kinase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

    See URA6 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (392526..393140, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene glutathione peroxidase GPX1 Neighboring gene Pan3p Neighboring gene Min9p Neighboring gene Ska1p

    Pathways from PubChem

    Interactions

    General gene information

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables (d)CMP kinase activity  
    enables (d)CMP kinase activity  
    enables ATP binding  
    enables UMP kinase activity  
    enables UMP kinase activity  
    enables UMP/dUMP kinase activity PubMed 
    enables UMP/dUMP kinase activity  
    enables UMP/dUMP kinase activity PubMed 
    enables adenylate kinase activity PubMed 
    enables adenylate kinase activity PubMed 
    enables kinase activity  
    Component Evidence Code Pubs
    is_active_in cytoplasm  
    located_in cytoplasm PubMed 
    located_in cytoplasm  
    is_active_in nucleus  
    located_in nucleus PubMed 
    located_in nucleus  

    General protein information

    Preferred Names
    bifunctional uridylate/adenylate kinase
    NP_012901.3
    • Uridylate kinase; catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP)

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      392526..393140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179590.3 → NP_012901.3  TPA: bifunctional uridylate/adenylate kinase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012901.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXR0, P15700
      UniProtKB/TrEMBL
      A6ZZT9, G2WI05, N1P0Q1
      Conserved Domains (1) summary
      TIGR01359
      Location:18 → 196
      UMP_CMP_kin_fam; UMP-CMP kinase family
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