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    fan-1 Fanconi-associated nuclease;Fanconi-associated nuclease 1 homolog [ Caenorhabditis elegans ]

    Gene ID: 177415, updated on 9-Dec-2024

    Summary

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    Official Symbol
    fan-1
    Official Full Name
    Fanconi-associated nuclease;Fanconi-associated nuclease 1 homolog
    Primary source
    WormBase:WBGene00015310
    Locus tag
    CELE_C01G5.8
    See related
    AllianceGenome:WB:WBGene00015310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable 5'-3' exonuclease activity; 5'-flap endonuclease activity; and flap-structured DNA binding activity. Involved in DNA repair. Located in nucleus. Is expressed in embryonic cell; germ cell; head neurons; intestine; and tail neurons. Used to study Fanconi anemia. Human ortholog(s) of this gene implicated in karyomegalic interstitial nephritis. Orthologous to human FAN1 (FANCD2 and FANCI associated nuclease 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See fan-1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    14
    Sequence:
    Chromosome: IV; NC_003282.8 (6548686..6552511)

    Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Adiponectin receptor protein 1;Progestin and adipoQ receptor-like protein 1 Neighboring gene ncRNA Neighboring gene tRNA-Leu Neighboring gene Peptidase S1 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003282.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Deficiency of FANCD2-associated nuclease KIAA1018/FAN1 sensitizes cells to interstrand crosslinking agents. Kratz K, et al. Cell, 2010 Jul 9. PMID 20603016
    2. LINC complexes promote homologous recombination in part through inhibition of nonhomologous end joining. Lawrence KS, et al. J Cell Biol, 2016 Dec 19. PMID 27956467, Free PMC Article
    3. A genetic screen identifies FAN1, a Fanconi anemia-associated nuclease necessary for DNA interstrand crosslink repair. Smogorzewska A, et al. Mol Cell, 2010 Jul 9. PMID 20603073, Free PMC Article
    4. Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2. MacKay C, et al. Cell, 2010 Jul 9. PMID 20603015, Free PMC Article
    5. Systematic analysis of DNA crosslink repair pathways during development and aging in Caenorhabditis elegans. Wilson DM 3rd, et al. Nucleic Acids Res, 2017 Sep 19. PMID 28934497, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables 5'-3' exonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-flap endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables flap-structured DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclease activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphodiesterase I activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in interstrand cross-link repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in interstrand cross-link repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Fanconi-associated nuclease;Fanconi-associated nuclease 1 homolog
    NP_001370919.1
    • Confirmed by transcript evidence
    NP_500997.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003282.8 Reference assembly

      Range
      6548686..6552511
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_068596.6 → NP_500997.1  Fanconi-associated nuclease 1 homolog [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_500997.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P90740
      Conserved Domains (1) summary
      pfam08774
      Location:751 → 858
      VRR_NUC; VRR-NUC domain

    2. NM_001383106.1 → NP_001370919.1  Fanconi-associated nuclease [Caenorhabditis elegans]

      Status: REVIEWED

      UniProtKB/TrEMBL
      V6CK03
      Conserved Domains (1) summary
      cd22326
      Location:1 → 432
      FAN1-like; repair nuclease FAN1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P90740.1

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