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    PER33 Per33p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850753, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PER33
    Official Full Name
    Per33p
    Primary source
    SGD:S000004054
    Locus tag
    YLR064W
    See related
    AllianceGenome:SGD:S000004054; FungiDB:YLR064W; VEuPathDB:YLR064W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to be involved in endoplasmic reticulum tubular network organization and membrane organization. Located in endoplasmic reticulum and nuclear envelope. Orthologous to human TMEM33 (transmembrane protein 33). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See PER33 in Genome Data Viewer
    Location:
    chromosome: XII
    Exon count:
    1
    Sequence:
    Chromosome: XII; NC_001144.5 (265456..266277)

    Chromosome XII - NC_001144.5Genomic Context describing neighboring genes Neighboring gene ribosomal 60S subunit protein L22A Neighboring gene 25S rRNA (uracil2843-N3)-methyltransferase Neighboring gene Snd2p Neighboring gene signal peptidase complex subunit SPC3

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001144.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The Princeton Protein Orthology Database (P-POD): a comparative genomics analysis tool for biologists. Heinicke S, et al. PLoS One, 2007 Aug 22. PMID 17712414, Free PMC Article
    2. Nuclear pore complex integrity requires Lnp1, a regulator of cortical endoplasmic reticulum. Casey AK, et al. Mol Biol Cell, 2015 Aug 1. PMID 26041935, Free PMC Article
    3. Pom33, a novel transmembrane nucleoporin required for proper nuclear pore complex distribution. Chadrin A, et al. J Cell Biol, 2010 May 31. PMID 20498018, Free PMC Article
    4. Nuclear pore targeting of the yeast Pom33 nucleoporin depends on karyopherin and lipid binding. Floch AG, et al. J Cell Sci, 2015 Jan 15. PMID 25413348
    5. Genetic analysis of Mps3 SUN domain mutants in Saccharomyces cerevisiae reveals an interaction with the SUN-like protein Slp1. Friederichs JM, et al. G3 (Bethesda), 2012 Dec. PMID 23275891, Free PMC Article

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in endoplasmic reticulum tubular network organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in membrane organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum HDA PubMed 
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear pore IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Per33p
    NP_013165.1
    • Protein that localizes to the endoplasmic reticulum; also associates with the nuclear pore complex; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001144.5 Reference assembly

      Range
      265456..266277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181951.1 → NP_013165.1  TPA: Per33p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013165.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VY65, Q12144
      UniProtKB/TrEMBL
      A7A0W9, B3LT34, B5VMZ7, C7GQN9, C8ZD36, G2WIQ6, N1NY22
      Conserved Domains (1) summary
      pfam03661
      Location:24 → 264
      UPF0121; Uncharacterized protein family (UPF0121)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12144.1

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