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    ERG13 hydroxymethylglutaryl-CoA synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854913, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ERG13
    Official Full Name
    hydroxymethylglutaryl-CoA synthase
    Primary source
    SGD:S000004595
    Locus tag
    YML126C
    See related
    AllianceGenome:SGD:S000004595; FungiDB:YML126C; VEuPathDB:YML126C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    HMGS
    Summary
    Enables hydroxymethylglutaryl-CoA synthase activity. Involved in ergosterol biosynthetic process. Located in nucleus. Human ortholog(s) of this gene implicated in HMG-CoA synthase 2 deficiency. Orthologous to several human genes including HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ERG13 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (19060..20535, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene Msc1p Neighboring gene Rsc9p Neighboring gene cytochrome-b5 reductase Neighboring gene alpha-tubulin TUB3 Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The biosynthesis of beta-hydroxy-beta-methylglutaryl coenzyme A in yeast. IV. The origin of the thioester bond of beta-hydroxy-beta-methylglutaryl coenzyme A. Stewart PR, et al. J Biol Chem, 1966 Mar 10. PMID 5933878
    2. Isolation and characterization of yeast mutants blocked in mevalonic acid formation. Servouse M, et al. Biochem Biophys Res Commun, 1984 Sep 17. PMID 6148937
    3. Engineering a functional 1-deoxy-D-xylulose 5-phosphate (DXP) pathway in Saccharomyces cerevisiae. Kirby J, et al. Metab Eng, 2016 Nov. PMID 27989805, Free PMC Article
    4. Dolichol biosynthesis in the yeast Saccharomyces cerevisiae: an insight into the regulatory role of farnesyl diphosphate synthase. Grabińska K, et al. FEMS Yeast Res, 2002 Aug. PMID 12702274
    5. The biosynthesis of beta-hydroxy-beta-methylglutaryl coenzyme A in yeast. I. Identification and purification of the hydroxymethylglutaryl coenzymecondensing enzyme. FERGUSON JJ Jr, et al. J Biol Chem, 1959 May. PMID 13654321

    See all (63) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables hydroxymethylglutaryl-CoA synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydroxymethylglutaryl-CoA synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydroxymethylglutaryl-CoA synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in acetyl-CoA metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in acetyl-CoA metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ergosterol biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ergosterol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sterol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    hydroxymethylglutaryl-CoA synthase
    NP_013580.1
    • 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase; catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      19060..20535 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182489.1 → NP_013580.1  TPA: hydroxymethylglutaryl-CoA synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013580.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0F9, P54839
      UniProtKB/TrEMBL
      A6ZLT9, B3LLD4, C7GVA7, C8ZE76, G2WJT1, N1NXW8
      Conserved Domains (1) summary
      TIGR01833
      Location:45 → 490
      HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P54839.1

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