PRM15 phosphoribomutase PRM15 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: PRM15
Official Full Name: phosphoribomutase PRM15
Primary source: SGD:S000004891
Locus tag: YMR278W
See related: AllianceGenome:SGD:S000004891; FungiDB:YMR278W; VEuPathDB:YMR278W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: PGM3
Summary: Enables phosphopentomutase activity. Involved in guanosine catabolic process; inosine catabolic process; and purine ribonucleoside salvage. Located in cytoplasm and nucleus. Orthologous to human PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2 like 1). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See PRM15 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (822763..824631)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The PGM3 gene encodes the major phosphoribomutase in the yeast Saccharomyces cerevisiae.
Title: The PGM3 gene encodes the major phosphoribomutase in the yeast Saccharomyces cerevisiae.
Based on the above results we suggest that YMR278w encodes phosphoglucomutase and not phosphoribomutase.
Title: Molecular characterization reveals that YMR278w encoded protein is environmental stress response homologue of Saccharomyces cerevisiae PGM2.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables intramolecular phosphotransferase activity	IEA Inferred from Electronic Annotation more info
enables isomerase activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables phosphopentomutase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphopentomutase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphopentomutase activity	IEA Inferred from Electronic Annotation more info
enables phosphopentomutase activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
involved_in carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in glucose metabolic process	IEA Inferred from Electronic Annotation more info
involved_in guanosine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inosine catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in purine ribonucleoside salvage	IBA Inferred from Biological aspect of Ancestor more info
involved_in purine ribonucleoside salvage	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	HDA more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: phosphoribomutase PRM15

NP_014005.1

EC 5.4.2.7

Phosphoribomutase; catalyzes interconversion of ribose-1-phosphate and ribose-5-phosphate; has some phosphoglucomutase activity but primary activity in vivo is phosphoribomutase; contributes to ribose recycling in the pentose phosphate pathway; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

822763..824631

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182785.1 → NP_014005.1 TPA: phosphoribomutase PRM15 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014005.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0A5, Q03262

UniProtKB/TrEMBL

B3LMG6, B5VQ45, C7GTM1, C8ZFE5, G2WKY7, N1P604

Conserved Domains (1) summary

cd05799
Location:52 → 596

PGM2; This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and ...