GPI12 N-acetylglucosaminylphosphatidylinositol deacetylase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Official Symbol: GPI12
Official Full Name: N-acetylglucosaminylphosphatidylinositol deacetylase
Primary source: SGD:S000004894
Locus tag: YMR281W
See related: AllianceGenome:SGD:S000004894; FungiDB:YMR281W; VEuPathDB:YMR281W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables N-acetylglucosaminylphosphatidylinositol deacetylase activity. Predicted to be involved in GPI anchor biosynthetic process. Located in endoplasmic reticulum. Human ortholog(s) of this gene implicated in CHIME syndrome. Orthologous to human PIGL (phosphatidylinositol glycan anchor biosynthesis class L). [provided by Alliance of Genome Resources, Dec 2024]
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Genomic context

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See GPI12 in Genome Data Viewer

Location:: chromosome: XIII

Exon count:: 1

Sequence:: Chromosome: XIII; NC_001145.3 (832339..833253)

Chromosome XIII - NC_001145.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001145.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression, purification, and characterization of N-acetylglucosaminylphosphatidylinositol de-N-acetylase (ScGpi12), the enzyme that catalyses the second step of GPI biosynthesis in S. cerevisiae.
Title: Expression, purification, and characterization of N-acetylglucosaminylphosphatidylinositol de-N-acetylase (ScGpi12), the enzyme that catalyses the second step of GPI biosynthesis in S. cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

px-64e4 (e-PCR)
- UniSTS:258445

Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables N-acetylglucosaminylphosphatidylinositol deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables N-acetylglucosaminylphosphatidylinositol deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables N-acetylglucosaminylphosphatidylinositol deacetylase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in GPI anchor biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in GPI anchor biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in endoplasmic reticulum	HDA more info	PubMed
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: N-acetylglucosaminylphosphatidylinositol deacetylase

NP_014008.1

EC 3.5.1.89

ER membrane protein involved in the second step of GPI anchor assembly; the second step is the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp; GPI stands for glycosylphosphatidylinositol

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001145.3 Reference assembly

Range

832339..833253

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182788.1 → NP_014008.1 TPA: N-acetylglucosaminylphosphatidylinositol deacetylase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014008.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W0A8, P23797

UniProtKB/TrEMBL

A6ZMZ7, B3LMG9, B5VQ49, C7GTL8, C8ZFE8, G2WKZ0, N1NXS0

Conserved Domains (1) summary

COG2120
Location:45 → 303

LmbE; N-acetylglucosaminyl deacetylase, LmbE family [Carbohydrate transport and metabolism]