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    ATP15 F1F0 ATP synthase subunit epsilon [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855857, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ATP15
    Official Full Name
    F1F0 ATP synthase subunit epsilon
    Primary source
    SGD:S000006192
    Locus tag
    YPL271W
    See related
    AllianceGenome:SGD:S000006192; FungiDB:YPL271W; VEuPathDB:YPL271W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Contributes to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Involved in proton motive force-driven ATP synthesis. Located in mitochondrion. Part of proton-transporting ATP synthase, central stalk. Used to study mitochondrial complex V (ATP synthase) deficiency nuclear type 3. Human ortholog(s) of this gene implicated in mitochondrial complex V (ATP synthase) deficiency nuclear type 3. Orthologous to human ATP5F1E (ATP synthase F1 subunit epsilon) and ATP5F1EP2 (ATP synthase F1 subunit epsilon pseudogene 2). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ATP15 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (30079..30267)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene S-adenosylmethionine-homocysteine S-methyltransferase SAM4 Neighboring gene Pbi1p Neighboring gene ATP-binding cassette permease MDL2 Neighboring gene Kar9p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Isolation and complete amino acid sequence of the mitochondrial ATP synthase epsilon-subunit of the yeast Saccharomyces cerevisiae. Arselin G, et al. J Biol Chem, 1991 Jan 15. PMID 1985960
    2. Absence of F1-ATPase activity in Kluyveromyces lactis lacking the epsilon subunit. Chen XJ. Curr Genet, 2000 Jul. PMID 10953875
    3. Biochemical investigation of a human pathogenic mutation in the nuclear ATP5E gene using yeast as a model. Sardin E, et al. Front Genet, 2015. PMID 25954304, Free PMC Article
    4. The absence of the mitochondrial ATP synthase delta subunit promotes a slow growth phenotype of rho- yeast cells by a lack of assembly of the catalytic sector F1. Giraud MF, et al. Eur J Biochem, 1997 May 1. PMID 9183023
    5. ATP synthase of yeast mitochondria. Isolation and disruption of the ATP epsilon gene. Guélin E, et al. J Biol Chem, 1993 Jan 5. PMID 8416924

    See all (77) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to ATP hydrolysis activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables proton-transporting ATP synthase activity, rotational mechanism IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to proton-transporting ATP synthase activity, rotational mechanism IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ATP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in proton motive force-driven ATP synthesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proton motive force-driven ATP synthesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in proton motive force-driven mitochondrial ATP synthesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proton transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase complex, catalytic core F(1) IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of proton-transporting ATP synthase, central stalk IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of proton-transporting ATP synthase, central stalk IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    F1F0 ATP synthase subunit epsilon
    NP_015052.1
    • Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase; which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; F1 translationally regulates ATP6 and ATP8 expression to achieve a balanced output of ATP synthase genes encoded in nucleus and mitochondria; phosphorylated

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      30079..30267
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184085.1 → NP_015052.1  TPA: F1F0 ATP synthase subunit epsilon [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015052.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W399, P21306
      UniProtKB/TrEMBL
      A6ZVY5, B3LKG2, C7GSH1, C8ZIA8, E9P9X4, G2WNR5, N1NXU9
      Conserved Domains (1) summary
      pfam04627
      Location:2 → 51
      ATP-synt_Eps; Mitochondrial ATP synthase epsilon chain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21306.2

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