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    HSP32 glutathione-independent methylglyoxalase family protein [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855849, updated on 9-Dec-2024

    Summary

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    Official Symbol
    HSP32
    Official Full Name
    glutathione-independent methylglyoxalase family protein
    Primary source
    SGD:S000006201
    Locus tag
    YPL280W
    See related
    AllianceGenome:SGD:S000006201; FungiDB:YPL280W; VEuPathDB:YPL280W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable glyoxalase III activity and protein folding chaperone. Involved in cellular response to nutrient levels and methylglyoxal catabolic process. Located in P-body and cytoplasmic stress granule. Used to study Parkinson's disease and cancer. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See HSP32 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (11887..12600)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene seripauperin PAU22 Neighboring gene phosphopyruvate hydratase ERR2 Neighboring gene fluoride transporter Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Saccharomyces cerevisiae DJ-1 paralogs maintain genome integrity through glycation repair of nucleic acids and proteins. Susarla G, et al. Elife, 2023 Aug 7. PMID 37548361, Free PMC Article
    2. The 1.8-A resolution crystal structure of YDR533Cp from Saccharomyces cerevisiae: a member of the DJ-1/ThiJ/PfpI superfamily. Wilson MA, et al. Proc Natl Acad Sci U S A, 2004 Feb 10. PMID 14745011, Free PMC Article
    3. Redox-dependent regulation of mitochondrial dynamics by DJ-1 paralogs in Saccharomyces cerevisiae. Bankapalli K, et al. Redox Biol, 2020 May. PMID 32070881, Free PMC Article
    4. Yeast DJ-1 superfamily members are required for diauxic-shift reprogramming and cell survival in stationary phase. Miller-Fleming L, et al. Proc Natl Acad Sci U S A, 2014 May 13. PMID 24706893, Free PMC Article
    5. Robust glyoxalase activity of Hsp31, a ThiJ/DJ-1/PfpI family member protein, is critical for oxidative stress resistance in Saccharomyces cerevisiae. Bankapalli K, et al. J Biol Chem, 2015 Oct 30. PMID 26370081, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glyoxalase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glyoxalase III activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein folding chaperone ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to nutrient levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaperone-mediated protein folding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    involved_in lactate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in methylglyoxal catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in P-body IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasmic stress granule HDA PubMed 
    located_in cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glutathione-independent methylglyoxalase family protein
    NP_015043.1
    • Possible chaperone and cysteine protease; required for transcriptional reprogramming during the diauxic shift and for survival in stationary phase; similar to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease and cancer

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      11887..12600
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184094.1 → NP_015043.1  TPA: glutathione-independent methylglyoxalase family protein [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015043.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W392, Q08992
      UniProtKB/TrEMBL
      A6ZVX8, B3LK44, B5VSR1, C8ZHD9, G2WL33
      Conserved Domains (1) summary
      cl00020
      Location:5 → 235
      GAT_1; Type 1 glutamine amidotransferase (GATase1)-like domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08992.1

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