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    COG4 Golgi transport complex subunit COG4 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856220, updated on 9-Dec-2024

    Summary

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    Official Symbol
    COG4
    Official Full Name
    Golgi transport complex subunit COG4
    Primary source
    SGD:S000006309
    Locus tag
    YPR105C
    See related
    AllianceGenome:SGD:S000006309; FungiDB:YPR105C; VEuPathDB:YPR105C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    COD1; SEC38; SGF1
    Summary
    Involved in cytoplasm to vacuole targeting by the Cvt pathway; pexophagy; and retrograde transport, vesicle recycling within Golgi. Located in cytosol. Part of Golgi transport complex. Human ortholog(s) of this gene implicated in Saul-Wilson syndrome and congenital disorder of glycosylation type IIj. Orthologous to human COG4 (component of oligomeric golgi complex 4). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See COG4 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (736984..739569, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene proteasome core particle subunit beta 5 Neighboring gene Fhl1p Neighboring gene putative protein kinase ISR1 Neighboring gene cleavage polyadenylation factor RNA-binding subunit YTH1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Relationship between endoplasmic reticulum- and Golgi-associated calcium homeostasis and 4-NQO-induced DNA repair in Saccharomyces cerevisiae. Poletto NP, et al. Arch Microbiol, 2010 Apr. PMID 20143049
    2. Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Shemorry A, et al. Mol Cell, 2013 May 23. PMID 23603116, Free PMC Article
    3. Molecular organization of the COG vesicle tethering complex. Lees JA, et al. Nat Struct Mol Biol, 2010 Nov. PMID 20972446, Free PMC Article
    4. Molecular architecture of the complete COG tethering complex. Ha JY, et al. Nat Struct Mol Biol, 2016 Aug. PMID 27428773, Free PMC Article
    5. Detailed Analysis of the Interaction of Yeast COG Complex. Ishii M, et al. Cell Struct Funct, 2018 Jul 19. PMID 29899178, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytoplasm to vacuole targeting by the Cvt pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intra-Golgi vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in macroautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pexophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, vesicle recycling within Golgi IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Golgi transport complex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    located_in cytosol HDA PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Golgi transport complex subunit COG4
    NP_015430.1
    • Essential component of the conserved oligomeric Golgi complex; a cytosolic tethering complex (Cog1p through Cog8p) that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      736984..739569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184202.1 → NP_015430.1  TPA: Golgi transport complex subunit COG4 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015430.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W4A3, Q06096
      UniProtKB/TrEMBL
      A6ZWY5, B3LK69, B5VTP5, C7GXR6, G2WPS1, N1P2A0
      Conserved Domains (1) summary
      smart00762
      Location:190 → 526
      Cog4; COG4 transport protein
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q06096.1

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