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    ceh-74 Homeobox domain-containing protein [ Caenorhabditis elegans ]

    Gene ID: 191149, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ceh-74
    Official Full Name
    Homeobox domain-containing protein
    Primary source
    WormBase:WBGene00013876
    Locus tag
    CELE_ZC376.4
    See related
    AllianceGenome:WB:WBGene00013876
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of transcription regulator complex. Predicted to be active in nucleus. Is expressed in several structures, including head mesodermal cell; hypodermis; neurons; reproductive system; and somatic nervous system. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See ceh-74 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    4
    Sequence:
    Chromosome: V; NC_003283.11 (14178079..14179628)

    Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Carboxylesterase type B domain-containing protein Neighboring gene Carboxylesterase type B domain-containing protein Neighboring gene Carboxylesterase type B domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene tRNA (guanine(26)-N(2))-dimethyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003283.11

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Unique homeobox codes delineate all the neuron classes of C. elegans. Reilly MB, et al. Nature, 2020 Aug. PMID 32814896, Free PMC Article
    2. A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis. Ma X, et al. Nat Methods, 2021 Aug. PMID 34312566
    3. A genome-wide study of PDZ-domain interactions in C. elegans reveals a high frequency of non-canonical binding. Lenfant N, et al. BMC Genomics, 2010 Nov 26. PMID 21110867, Free PMC Article
    4. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article
    5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Homeobox domain-containing protein
    NP_506511.1
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003283.11 Reference assembly

      Range
      14178079..14179628
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_074110.4 → NP_506511.1  Homeobox domain-containing protein [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_506511.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q23269
      Conserved Domains (2) summary
      smart00389
      Location:24 → 62
      HOX; Homeodomain
      cl15755
      Location:180 → 238
      SAM_superfamily; SAM (Sterile alpha motif )
    Nucleotide Protein
    Heading Accession and Version

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